ArticleNMR in biomedicine2023
Diffusion MRI with pulsed and free gradient waveforms: Effects of restricted diffusion and exchange.
Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.Magnetic resonance in medicine · 2026Article
- Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.NMR in biomedicine · 2026Article
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.Magnetic resonance letters · 2026Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- Decoding gray matter, large-scale analysis of brain cell morphometry to inform microstructural modeling of diffusion MR signals.Communications biology · 2026Article
- Modeling the MRI gradient system with a temporal convolutional network: Improved reconstruction by prediction of readout gradient errors.Magnetic resonance in medicine · 2026Article
- Validation of diffusion and exchange imaging biomarkers via simultaneous real-time NMR and optical microscopy.bioRxiv : the preprint server for biology · 2025Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.bioRxiv : the preprint server for biology · 2025Article
- Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- Revealing membrane integrity and cell size from diffusion kurtosis time dependence.Magnetic resonance in medicine · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac.Medical physics · 2025Article
- Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?NMR in biomedicine · 2024Article
- The Diffusion Exchange Ratio (DEXR): A minimal sampling of diffusion exchange spectroscopy to probe exchange, restriction, and time-dependence.bioRxiv : the preprint server for biology · 2024Article
- Diffusional kurtosis time dependence and the water exchange rate for the multi-compartment Kärger model.Magnetic resonance in medicine · 2024Article
- On the sampling strategies and models for measuring diffusion exchange with a double diffusion encoding sequence.Magnetic resonance letters · 2023Article
- Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo.Magnetic resonance in medicine · 2023Article
- Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces.Magnetic resonance letters · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Monitoring time dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted diffusion and exchange have opposite effects on the diffusion-weighted signal, which can lead to errors in parameter estimates. In this work, we propose a signal representation that incorporates the effects of both restricted diffusion and exchange up to second order in b-value and is compatible with gradient waveforms of arbitrary shape. The representation features mappings from a gradient waveform to two scalars that separately control the sensitivity to restriction and exchange. We demonstrate that these scalars span a two-dimensional space that can be used to choose waveforms that selectively probe restricted diffusion or exchange, eliminating the correlation between the two phenomena. We found that waveforms with specific but unconventional shapes provide an advantage over conventional pulsed and oscillating gradient acquisitions. We also show that parametrization of waveforms into a two-dimensional space can be used to understand protocols from other approaches that probe restricted diffusion and exchange. For example, we found that the variation of mixing time in filter-exchange imaging corresponds to variation of our exchange-weighting scalar at a fixed value of the restriction-weighting scalar. The proposed signal representation was evaluated using Monte Carlo simulations in identical parallel cylinders with hexagonal and random packing as well as parallel cylinders with gamma-distributed radii. Results showed that the approach is sensitive to sizes in the interval 4-12
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.