ArticleScience (New York, N.Y.)2022
Evolutionary gain and loss of a pathological immune response to parasitism.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Rates of Evolution Differ Between Cell Types Identified by Single-Cell RNAseq in Threespine Stickleback.Molecular ecology · 2026Article
- Eco-Evolutionary Dynamics of Infection and Immunity in Experimentally Founded Lake Populations of Threespine Stickleback.The American naturalist · 2026Article
- Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations.bioRxiv : the preprint server for biology · 2026Article
- Markedly reduced prevalence of Schistocephalus solidus in pelagic three-spined sticklebacks (Gasterosteus aculeatus) from Lake Constance.Parasitology research · 2026Article
- Testing vivo-morpholino mediated gene knockdown in threespine stickleback.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial heterogeneity drives the evolution of fungicide resistance inScience advances · 2026Article
- Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes.Molecular biology and evolution · 2026Article
- Article
- Changes in gene regulation are associated with the evolution of resistance to a novel parasite.Frontiers in immunology · 2026Article
- Heritable differences in metabolic stability underpin thermal tolerance of threespine stickleback (bioRxiv : the preprint server for biology · 2025Article
- Trophic dynamics and metabolic pathways in host parasite interactions revealed by nitrogen isotope analysis of amino acids in multiple tissues.Scientific reports · 2025Article
- Rapid genome-wide introgression reveals fitness advantage of immigrant genotypes.bioRxiv : the preprint server for biology · 2025Article
- Dynamics of infection and immunity over 50 years as marine stickleback adapt to freshwater.Evolution letters · 2025Article
- A portrait of 2 nematodes in liver of their paratenic fish hosts, illustrating different immunological approaches.Parasitology · 2025Article
- Resource reallocation under persistent immune activation drives trade-offs between life history and immunity in pirk-deficient Musca domestica.BMC biology · 2025Article
- Conservation Evolutionary Biology: A Unified Framework Connecting the Past, Present, and Future of Biodiversity Conservation.Molecular biology and evolution · 2025Review
- Among-population proteomic differences in Schistocephalus solidus based on excretory/secretory and total body protein predictions.Parasites & vectors · 2025Article
- A spectral framework to map QTLs affecting joint differential networks of gene co-expression.PLoS computational biology · 2025Article
- Host Disease Tolerance Predicts Transmission Probability for a Songbird Pathogen.Ecology and evolution · 2025Article
- Does Motility-Restricting Fibrosis Influence Dispersal? An Experiment in Nature With Threespine Stickleback.Ecology and evolution · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Parasites impose fitness costs on their hosts. Biologists often assume that natural selection favors infection-resistant hosts. Yet, when the immune response itself is costly, theory suggests that selection may sometimes favor loss of resistance, which may result in alternative stable states where some populations are resistant and others are tolerant. Intraspecific variation in immune costs is rarely surveyed in a manner that tests evolutionary patterns, and there are few examples of adaptive loss of resistance. Here, we show that when marine threespine stickleback colonized freshwater lakes, they gained resistance to the freshwater-associated cestode
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.