Evidence map›Paper›PMID 36074833›Full record

ArticleScience (New York, N.Y.)2022

COVID-19 and children.

Carl A Pierce, Kevan C Herold, Betsy C Herold, Janet Chou, Adrienne Randolph, Binita Kane, Sammie McFarland, Deepti Gurdasani, Christina Pagel, Peter Hotez and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 67 citations in OpenAlex.

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  11. Tunisian Pediatricians' Attitudes and Practices Toward COVID-19 Immunization and Other Vaccines.International journal of environmental research and public health · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 2 countries.

Carl A PierceDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Kevan C HeroldDepartments of Immunobiology and of Medicine, Yale School of Medicine, New Haven, CT, USA.
Betsy C HeroldDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Janet ChouDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Adrienne RandolphDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Binita KaneManchester University Foundation Trust and School of Biological Sciences, University of Manchester, Manchester, UK.
Sammie McFarlandLong Covid Kids & Friends Charity, Crowhurst, UK.
Deepti GurdasaniWilliam Harvey Research Institute, Queen Mary University of London, London, UK.
Christina PagelClinical Operational Research Unit, University College London, London, UK.
Peter HotezTexas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Sarah CobeyDepartment of Ecology and Evolution, University of Chicago, Illinois, USA.
Scott E HensleyDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.
Albert Einstein College of Medicine · USBoston Children's Hospital · USHarvard University · USManchester University NHS Foundation Trust · GBRice University · USUniversity College London · GBUniversity of Chicago · USUniversity of Pennsylvania · USWilliam Harvey Research Institute · GB

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENSLEY, SCOTT · 2021 to 2025
$50.7M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Training in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6M
Mechanisms Underlying the HIV-HSV-2 SyndemicR01AI134367 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Betsy C. Herold · 2018 to 2026
$4.9M
Medical Research Council MR/S003711/1Medical Research Council MR/S003711/2NIAID NIH HHS 75N93021C00015NIAID NIH HHS R01 AI134367NIAID NIH HHS T32 AI007501NIDDK NIH HHS P30 DK045735NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

There has been substantial research on adult COVID-19 and how to treat it. But how do severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections afflict children? The COVID-19 pandemic has yielded many surprises, not least that children generally develop less severe disease than older adults, which is unusual for a respiratory disease. However, some children can develop serious complications from COVID-19, such as multisystem inflammatory syndrome in children (MIS-C) and Long Covid, even after mild or asymptomatic COVID-19. Why this occurs in some and not others is an important question. Moreover, when children do contract COVID-19, understanding their role in transmission, especially in schools and at home, is crucial to ensuring effective mitigation measures. Therefore, in addition to nonpharmaceutical interventions, such as improved ventilation, there is a strong case to vaccinate children so as to reduce possible long-term effects from infection and to decrease transmission. But questions remain about whether vaccination might skew immune responses to variants in the long term. As the experts discuss below, more is being learned about these important issues, but much more research is needed to understand the long-term effects of COVID-19 in children.

Indexed as

COVID-19PandemicsSystemic Inflammatory Response SyndromeAgedChildHumansPost-Acute COVID-19 SyndromeSARS-CoV-2

Identifiers

PMID36074833
PMCPMC10324476
OpenAlexW4295084880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.