Evidence map›Paper›PMID 36074814›Full record

ArticleACS biomaterials science & engineering2022

Hydrolytically Degradable PEG-Based Inverse Electron Demand Diels-Alder Click Hydrogels.

Nathan H Dimmitt, Matthew R Arkenberg, Mariana Moraes de Lima Perini, Jiliang Li, Chien-Chi Lin

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathan H DimmittDepartment of Biomedical Engineering, Purdue School of Engineering & Technology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.
Matthew R ArkenbergWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Mariana Moraes de Lima PeriniDepartment of Biology, Purdue School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.
Jiliang LiDepartment of Biology, Purdue School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.
Chien-Chi LinDepartment of Biomedical Engineering, Purdue School of Engineering & Technology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-4175-8796

Funding

Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - LOADR01AG060621 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KACENA, MELISSA A, LI, JILIANG · 2019 to 2023
$3.7M
Dynamic Double Network Hydrogel for Generating Pancreatic Organoids from InducedPluripotent Stem CellsR01DK127436 · NIDDK · PURDUE UNIVERSITY · PI LIN, CHIEN-CHI · 2022 to 2025
$1.8M
BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia: Admin SuppR01CA227737 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, CHIEN-CHI · 2019 to 2022
$1.5M
NCI NIH HHS R01 CA227737NIA NIH HHS R01 AG060621NIDDK NIH HHS R01 DK127436
6 · The paper itself

Abstract

Hydrogels cross-linked by inverse electron demand Diels-Alder (iEDDA) click chemistry are increasingly used in biomedical applications. With a few exceptions in naturally derived and chemically modified macromers, iEDDA click hydrogels exhibit long-term hydrolytic stability, and no synthetic iEDDA click hydrogels can undergo accelerated and tunable hydrolytic degradation. We have previously reported a novel method for synthesizing norbornene (NB)-functionalized multiarm poly(ethylene glycol) (PEG), where carbic anhydride (CA) was used to replace 5-norbornene-2-carboxylic acid. The new PEGNB

Indexed as

Biocompatible MaterialsElectronsAnhydridesCarboxylic AcidsHydrogelsNorbornanesPolyethylene GlycolsSulfhydryl Compounds2-norborneneAnhydridesBiocompatible MaterialsCarboxylic AcidsHydrogelsNorbornanesPolyethylene GlycolsSulfhydryl Compoundscell encapsulationdegradationhydrogelsiEDDA click reactioninjectable

Identifiers

PMID36074814
PMCPMC9554872

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.