Evidence map›Paper›PMID 36074657›Full record

ArticleCirculation. Arrhythmia and electrophysiology2022

Pulsed Field Ablation of the Porcine Ventricle Using a Focal Lattice-Tip Catheter.

Iwanari Kawamura, Vivek Y Reddy, Bingyan J Wang, Srinivas R Dukkipati, Hina W Chaudhry, Carlos G Santos-Gallego, Jacob S Koruth

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Ventricular pulsed field ablation from bench to bedside: preclinical and clinical evidence from a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  2. Specific effects of Pulsed Field Ablation on the cardiac tissue, the nervous system and the conduction system in experimental and clinical studies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Review
  3. Article
  4. Article
  5. Advancements in mapping, cardiac imaging, and ablation techniques for the management of ventricular tachycardias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  6. Article
  7. Epicardial ventricular tachycardia ablation with a pentaspline catheter during left ventricular assist device placement.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  8. Review
  9. A novel pulsed field ablation system using linear and spiral ablation catheters can create large and durable endocardial and epicardial ventricular lesions in vivo.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  10. Article
  11. Safety and efficacy of a lattice-tip catheter for ventricular arrhythmia ablation: the AFFERA Ventricular Arrhythmia Ablation Registry (AVAAR).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  12. Role of Computational Modelling in Enhancing Thermal Safety During Cardiac Ablation.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias.Journal of cardiovascular development and disease · 2024
    Review
  18. Article
  19. Pulsed Field Ablation: A Comprehensive Update.Journal of clinical medicine · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Iwanari KawamuraHelmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-6431-9278
Vivek Y ReddyHelmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-5638-4993
Bingyan J WangCardiovascular Regenerative Medicine (B.J.W., H.W.C.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-3522-2848
Srinivas R DukkipatiHelmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-0931-7704
Hina W ChaudhryCardiovascular Regenerative Medicine (B.J.W., H.W.C.), Icahn School of Medicine at Mount Sinai, New York, NY.
Carlos G Santos-GallegoAtherothrombosis Research Unit, Department of Cardiology (C.G.S.-G.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-1408-8958
Jacob S KoruthHelmsley Electrophysiology Center (I.K., V.Y.R., S.R.D., J.S.K.), Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-2221-8372
Icahn School of Medicine at Mount Sinai · US

Funding

Human CDX2 Cells and Cardiac RepairR01HL150345 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHAUDHRY, HINA W · 2020 to 2023
$2.8M
NHLBI NIH HHS R01 HL150345
6 · The paper itself

Abstract

backgroundOur understanding of catheter-based pulsed field ablation (PFA) of the ventricular myocardium is limited. We conducted a series of exploratory evaluations of ventricular PFA in swine ventricles.

methodsA focal lattice-tip catheter was used to deliver proprietary biphasic monopolar PFA applications to swine ventricles under general anesthesia, with guidance from electroanatomical mapping, fluoroscopy, and intracardiac echocardiography. We conducted experiments to assess the impact of (1) delivery repetition (2×, 3×, or 4×) at each location, (2) epicardial PFA delivery, and (3) confluent areas of shallow healed endocardial scar created by prior PFA (4 weeks earlier) on subsequent endocardial PFA. Additional assessments included PFA optimized for the ventricle, lesion visualization by intracardiac echocardiography imaging, and immunohistochemical insights.

resultsExperiment no. 1: lesions (n=49) were larger with delivery repetition of either 4× or 3× versus 2×: length 17.6±3.9 or 14.2±2.0 versus 12.7±2.0 mm (

conclusionsThis in vivo evaluation offers insights into the behavior of endocardial or epicardial PFA delivered using the lattice-tip catheter to normal or scarred porcine ventricular myocardium, thereby setting the stage for future clinical studies.

Indexed as

Catheter AblationCicatrixAnimalsCathetersEndocardiumHeart VentriclesSwinecatheter ablationelectroporationimmunohistochemistrymyocardiumswinetachycardia,ventricular

Identifiers

PMID36074657
PMCPMC9794124
OpenAlexW4294990798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.