Evidence map›Paper›PMID 36073832›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Wireless-Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing.

Qianni Wu, Cheng Yang, Wan Chen, Kexin Chen, Hui-Jiuan Chen, Fanmao Liu, Dong Liu, Haotian Lin, Xi Xie, Weirong Chen

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Wearable Battery-Free Electrotherapy of Smartsensors for Wound Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Review
  5. Electrical Microneedles for Wound Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Wireless-Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qianni WuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Cheng YangState Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510006, China.
Wan ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Kexin ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Hui-Jiuan ChenState Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510006, China.
Fanmao LiuState Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510006, China.
Dong LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Haotian LinState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Xi XieState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
Weirong ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.ORCID 0000-0002-3023-4057
Sun Yat-sen University · CN

Funding

Fundamental Research Funds of the State Key Laboratory of Ophthalmology 2022QN06Fundamental Research Funds of the State Key Laboratory of Ophthalmology 2022QN07Guangdong Basic and Applied Basic Research Foundation 2020A1515010987Guangdong Basic and Applied Basic Research Foundation 2020A1515110424National Key R&D Program of China 2020YFC2008200National Key R&D Program of China 2021YFF1200700National Natural Science Foundation of China 32171399National Natural Science Foundation of China 81970778National Natural Science Foundation of China 82101099Science and Technology Program of Guangzhou 202102010231
6 · The paper itself

Abstract

Corneal injury can lead to severe vision impairment or even blindness. Although numerous methods are developed to accelerate corneal wound healing, most of them are passive treatments that rarely participate in controlling endogenous cell behaviors or are incompatible with nontransparent bandage. In this work, a wireless-powered electrical bandage contact lens (EBCL) is developed to generate a localized external electric field to accelerate corneal wound healing and vision recovery. The wireless electrical stimulation circuit employed a flower-shaped layout design that can be compactly integrated on bandage contact lens without blocking the vision. The role of the external electric field in promoting corneal wound healing is examined in vitro, where the responses of directional migration and corneal cells alignment to the electric field are observed. The RNA sequencing (RNA-seq) analysis indicates that the electrical stimulation can participate in controlling cell division, proliferation, and migration. Furthermore, the wireless EBCL is demonstrated to accelerate the completed recovery of corneal wounds on rabbits' eyes by electrical stimulation, while the control group exhibits delayed recovery and obvious corneal defects. As a new generation of intelligent device, the wireless and patient-friendly EBCL can provide a promising therapeutic strategy for ocular diseases.

Indexed as

Contact Lenses, HydrophilicCorneal InjuriesAnimalsBandagesCorneaRabbitsWound Healingbandage contact lenscornea wound healingelectrotherapywireless powered

Identifiers

PMID36073832
PMCPMC9631068
OpenAlexW4294992310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.