Evidence map›Paper›PMID 36073813›Full record

ArticlemBio2022

Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence.

Yi-Wei Chen, Martha I Camacho, Yimin Chen, Aadil H Bhat, Chungyu Chang, Emily A Peluso, Chenggang Wu, Asis Das, Hung Ton-That

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Caenorhabditis elegans as a Model Host for Fusobacterium nucleatum.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Journal of bacteriology · 2025
    Review
  11. Article
  12. Article
  13. Inactivation of thebioRxiv : the preprint server for biology · 2025
    Article
  14. Review
  15. Article
  16. Dencichine attenuates the virulence of Fusobacterium nucleatum by targeting hydrogen sulfide-producing enzyme.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  17. Article
  18. Article
  19. Ethanolamine-induced assembly of microcompartments is required forbioRxiv : the preprint server for biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi-Wei Chen *Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Martha I Camacho *Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Yimin ChenDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Aadil H BhatDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Chungyu ChangDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Emily A PelusoMolecular Biology Institute, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.
Chenggang WuDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, Texas, USA.
Asis DasDepartment of Medicine, Neag Comprehensive Cancer Center, University of Connecticut Health Centergrid.208078.5, Farmington, Connecticut, USA.
Hung Ton-ThatDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angelesgrid.19006.3e, Los Angeles, California, USA.ORCID 0000-0003-1611-0469
University of California, Los Angeles · USCzech Academy of Sciences, Institute of Microbiology · CZThe University of Texas Health Science Center at Houston · US

Funding

Virulence determinants of Fusobacterium nucleatumR01DE026758 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TON-THAT, HUNG · 2017 to 2021
$2.0M
Regulation in Fusobacterium-mediated coaggregationR01DE030895 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, CHENGGANG · 2021 to 2025
$1.7M
NIDCR NIH HHS R01 DE026758NIDCR NIH HHS R01 DE030895
6 · The paper itself

Abstract

The Gram-negative anaerobe Fusobacterium nucleatum is a major producer of hydrogen sulfide (H

Indexed as

Hydrogen SulfidePremature BirthAnimalsAnti-Bacterial AgentsCysteineFemaleFusobacterium nucleatumHumansInfant, NewbornKanamycinMiceNalidixic AcidPregnancySulfur CompoundsVirulenceAnti-Bacterial AgentsCysteineHydrogen SulfideKanamycinNalidixic AcidSulfur Compoundselectron microscopyFusobacterium nucleatumhydrogen sulfidelanthioninemetabolismplacentapreterm birthvirulence

Identifiers

PMID36073813
PMCPMC9600241
OpenAlexW4294992240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.