Evidence map›Paper›PMID 36073780›Full record

ArticleJournal of leukocyte biology2022

Dectin-1 signaling in neutrophils up-regulates PD-L1 and triggers ROS-mediated suppression of CD4

M Elizabeth Deerhake, Emre D Cardakli, Mari L Shinohara

Open access · greenAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Innate immune recognition ofInfection and immunity · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M Elizabeth DeerhakeDepartment of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-4061-5766
Emre D CardakliDepartment of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
Mari L ShinoharaDepartment of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · USMemorial Sloan Kettering Cancer Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Role of osteopontin in innate immunity during infections and inflammationR01AI088100 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2011 to 2021
$4.3M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Protective role of Clec7a/dectin-1 in CNS autoimmunityR01NS120417 · NINDS · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.0M
Protective role of dectin-1 signaling in an animal model of Multiple SclerosisF30AI140497 · NIAID · DUKE UNIVERSITY · PI DEERHAKE, MARION ELIZABETH · 2018 to 2021
$169k
NIAID NIH HHS F30 AI140497NIAID NIH HHS R01 AI088100NIAID NIH HHS R01 AI160737NIGMS NIH HHS T32 GM007171NINDS NIH HHS R01 NS120417
6 · The paper itself

Abstract

Dectin-1 is known to drive proinflammatory cytokine production by macrophages and dendritic cells which promotes Th17 CD4

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalNeutrophilsAnimalsB7-H1 AntigenDectin-1Lectins, C-TypeReactive Oxygen SpeciesTh17 CellsB7-H1 AntigenDectin-1Lectins, C-TypeReactive Oxygen Speciescheck-point moleculedectin-1PD-L1

Identifiers

PMID36073780
PMCPMC9701158
OpenAlexW4294992887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.