Evidence map›Paper›PMID 36073640›Full record

ArticleBiostatistics (Oxford, England)2023

Multiple exposure distributed lag models with variable selection.

Joseph Antonelli, Ander Wilson, Brent A Coull

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Multi-Tree Model for Precision Environmental Health with Longitudinally Assessed Mixture Exposure.Journal of the Royal Statistical Society. Series C, Applied statistics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph AntonelliDepartment of Statistics, University of Florida, 102 Griffin-Floyd Hall, Gainesville, FL, USA.
Ander WilsonDepartment of Statistics, Colorado State University, 851 Oval Drive, Fort Collins, CO 80523, USA.ORCID 0000-0003-4774-3883
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Spatial patterns of metals and metal mixtures in drinking waterP42ES030990 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI LU, QUAN · 2020 to 2024
$8.3M
Methods for Data Integration and Risk Assessment for Environmental MixturesR01ES028811 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COULL, BRENT ANDREW, GENNINGS, CHRIS · 2018 to 2021
$1.9M
EPA R835872NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P42 ES030990NIH HHS ES028811
6 · The paper itself

Abstract

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time periods during which exposure to a pollutant adversely affects health outcomes. Recent studies have focused on estimating the health effects of a large number of environmental exposures, or an environmental mixture, on health outcomes. In such settings, it is important to understand which environmental exposures affect a particular outcome, while acknowledging the possibility that different exposures have different critical windows. Further, in studies of environmental mixtures, it is important to identify interactions among exposures and to account for the fact that this interaction may occur between two exposures having different critical windows. Exposure to one exposure early in time could cause an individual to be more or less susceptible to another exposure later in time. We propose a Bayesian model to estimate the temporal effects of a large number of exposures on an outcome. We use spike-and-slab priors and semiparametric distributed lag curves to identify important exposures and exposure interactions and discuss extensions with improved power to detect harmful exposures. We then apply these methods to estimate the effects of exposure to multiple air pollutants during pregnancy on birthweight from vital records in Colorado.

Indexed as

Air PollutantsAir PollutionEnvironmental PollutantsBayes TheoremEnvironmental ExposureFemaleHumansParticulate MatterPregnancyAir PollutantsEnvironmental PollutantsParticulate MatterCritical windows of exposureEnvironmental mixtureFunctional data analysisScalar-on-function regression

Identifiers

PMID36073640
PMCPMC10724118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.