Evidence map›Paper›PMID 36073636›Full record

ArticleJournal of the American Heart Association2022

Risk of Postdischarge Bleeding From Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Among US Black and White Adults.

Brittain Heindl, Stephen Clarkson, Vibhu Parcha, Chrisly Dillon, Renuka Narayan, Ebikere Usifo, William Hillegass, Marguerite R Irvin, Pankaj Arora, Guihua Zhai and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Drug-Coated Balloon in Primary Percutaneous Coronary Intervention.Journal of interventional cardiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Brittain HeindlDivision of Cardiovascular Diseases, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-0961-3562
Stephen ClarksonDivision of Cardiovascular Diseases, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-7923-9676
Vibhu ParchaDivision of Cardiovascular Diseases, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-4993-8177
Chrisly DillonDepartment of Neurology University of Alabama at Birmingham Birmingham AL.
Renuka NarayanDepartment of Neurology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-9825-2542
Ebikere UsifoDepartment of Neurology University of Alabama at Birmingham Birmingham AL.
William HillegassDepartment of Data Science, School of Public Health University of Mississippi Medical Center Jackson MS.ORCID 0000-0001-6428-0564
Marguerite R IrvinDepartment of Epidemiology University of Alabama at Birmingham Birmingham AL.
Pankaj AroraDivision of Cardiovascular Diseases, Department of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0003-2420-3550
Guihua ZhaiDepartment of Biostatistics University of Alabama at Birmingham Birmingham AL.
Mark BeasleySchool of Public Health University of Alabama at Birmingham Birmingham AL.
Nita LimdiDepartment of Neurology University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-4672-8406
University of Alabama at Birmingham · USJackson Memorial Hospital · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI LIRETTE, SETH · 2016 to 2025
$38.2M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
Basic and Translational Science in Heart FailureT32HL129948 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2017 to 2021
$1.4M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
NCATS NIH HHS UL1 TR000165NHLBI NIH HHS K24 HL133373NHLBI NIH HHS T32 HL129948NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Background Dual antiplatelet therapy after percutaneous coronary intervention reduces myocardial infarctions but increases bleeding. The risk of bleeding may be higher among Black patients for unknown reasons. Bleeding risk scores have not been validated among Black patients. We assessed the difference in bleeding risk between Black and White patients along with the performance of the Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Anti Platelet Therapy, Patterns of Nonadherence to Antiplatelet Regimens in Stented Patients, and Academic Research Consortium for High Bleeding Risk scores among both groups. Methods and Results This was a single-center prospective study of patients who underwent percutaneous coronary intervention (2014-2019) and were followed for 1 year. The outcome was postdischarge Bleeding Academic Research Consortium 2 to 5 bleeding. Incidence rates were reported. Cox proportional hazards models measured the effect of self-reported Black race on bleeding and determined the predictors of bleeding among 19 a priori variables. The 3 risk scores were assessed among Black and White patients separately using the Harrell concordance index. Of 1529 included patients, 342 (22.4%) self-reported as being Black race. Unadjusted bleeding rates were 22.7 per 100 person-years among Black patients versus 16.3 among White patients (hazard ratio, 1.41 [95% CI, 1.00-2.00],

Indexed as

Acute Coronary SyndromePercutaneous Coronary InterventionAftercareAnticoagulantsDual Anti-Platelet TherapyHemorrhageHumansPatient DischargePlatelet Aggregation InhibitorsPrasugrel HydrochlorideProspective StudiesRisk AssessmentTicagrelorTreatment OutcomeAnticoagulantsPlatelet Aggregation InhibitorsPrasugrel HydrochlorideTicagrelorincidencepercutaneous coronary interventionplatelet aggregation inhibitorsprasugrel hydrochlorideproportional hazards modelsprospective studiesticagrelor

Identifiers

PMID36073636
PMCPMC9683679
OpenAlexW4294992143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.