ArticleJournal of the American Heart Association2022
Demographic and Regional Trends in Stroke-Related Mortality in Young Adults in the United States, 1999 to 2019.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Stroke in the Young: Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study.Neurology · 2026Article
- Trends and Demographic Disparities Among Adults With Sudden Cardiac Death and Diabetes Mellitus in the United States: A Nationwide Analysis.Journal of arrhythmia · 2026Article
- Patterns and trends of mortality in patients with arrhythmia and cerebrovascular disease in the United States: a nationwide analysis of older adults.Scientific reports · 2026Article
- Rising Burden of Hypertensive Heart Disease Mortality Among Young Adults in the United States, 1999 to 2024.The American journal of cardiology · 2026Article
- In-hospital survival and predictors of mortality among stroke patients at a tertiary hospital in Ghana: A retrospective cohort study.PloS one · 2026Article
- Trends and disparities in deaths involving atherosclerotic cardiovascular disease and stroke-related conditions among U.S. adults, 1999-2025.Frontiers in cardiovascular medicine · 2026Article
- Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.Stroke · 2025Observational
- Trends and Disparities in Stroke Mortality Among Adults with Hyperlipidemia in the United States, 1999-2023.Journal of epidemiology and global health · 2025Article
- Exploring the rising death rates among older US citizens with heart failure and sepsis: Need for health-care policy reform.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Demographic and regional trends of acute myocardial infarction-related mortality among young adults in the US, 1999-2020.NPJ cardiovascular health · 2025Article
- Review
- Trends in pancreatic cancer mortality in the United States 1999-2020: a CDC database population-based study.Cancer causes & control : CCC · 2024Article
- Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21-Year Retrospective Analysis of CDC-WONDER Database.Clinical cardiology · 2024Article
- Article
- Trends and Disparities in Valvular Heart Disease Mortality in the United States From 1999 to 2020.Journal of the American Heart Association · 2024Article
- Racial Impact on Inpatient Stroke Quality of Care in Two Community Hospitals.Journal of clinical medicine · 2023Article
- Both Moderate and Heavy Alcohol Use Amplify the Adverse Cardiovascular Effects of Smoking in Young Patients with Hypertension.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Despite improvements in the management and prevention of stroke, increasing hospitalizations for stroke and stagnant mortality rates have been described in young adults. However, there is a paucity of contemporary national mortality estimates in young adults. Methods and Results Trends in mortality related to stroke in young adults (aged 25-64 years) were assessed using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Age-adjusted mortality rates per 100 000 people with associated annual percentage change were calculated. Joinpoint regression was used to assess the trends in the overall sample and different demographic (sex, race and ethnicity, and age) and geographical (state, urban-rural, and regional) subgroups. Between 1999 and 2019, a total of 566 916 stroke-related deaths occurred among young adults. After the initial decline in mortality in the overall population, age-adjusted mortality rate increased from 2013 to 2019 with an associated annual percentage change of 1.5 (95% CI, 1.1-2.0). Mortality rates were higher in men versus women and in non-Hispanic Black people versus individuals of other races and ethnicities. Non-Hispanic American Indian or Alaskan Native people had a marked increase in stroke-related mortality (annual percentage change 2010-2019: 3.3). Furthermore, rural (nonmetropolitan) counties experienced the greatest increase in mortality (annual percentage change 2012-2019: 3.1) compared with urban (metropolitan) counties. Conclusions Following the initial decline in stroke-related mortality, young adults have experienced increasing mortality rates from 2013 to 2019, with considerable differences across demographic groups and regions.
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