ArticleeLife2022
Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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0cells of the map it votes in
35citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Influenza-induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice.Physiological reports · 2026Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026Article
- Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.Nature communications · 2026Article
- Review
- High-Altitude Hypoxic Preconditioning Attenuates Lipopolysaccharide-Induced Lung Injury and is Associated with Alveolar-Capillary Barrier Maintenance.Journal of inflammation research · 2026Article
- Tuft cell-mediated pathogen sensing and inflammation resolution.Biochemical Society transactions · 2025Review
- Specialized gas-exchange endothelium of the zebrafish gill.bioRxiv : the preprint server for biology · 2025Article
- Protective or pathogenic? Tuft cells shape divergent immune outcomes in helminth and viral infections.Current opinion in immunology · 2025Review
- Differential expression of haematopoietic prostaglandin D synthase by POU2F3‑positive tuft cells in conventional bilayered oncocytic and metaplastic epithelia of Warthin tumours.Molecular medicine reports · 2025Article
- Lung cell fates during influenza.Cell research · 2025Review
- Cellular heterogeneity and patterning strategies as revealed by upper respiratory epithelium single cell atlas.iScience · 2025Article
- Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro.Nature communications · 2025Article
- Article
- Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024Review
- Overloading And unpacKing (OAK) - droplet-based combinatorial indexing for ultra-high throughput single-cell multiomic profiling.Nature communications · 2024Article
- Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli.The Journal of clinical investigation · 2024Article
- Enteric tuft cells coordinate timely expulsion of the tapeworm Hymenolepis diminuta from the murine host by coordinating local but not systemic immunity.PLoS pathogens · 2024Article
- G protein subunit GeLife · 2024Article
- Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites.The Journal of allergy and clinical immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Justinn Barr *Department of Pediatrics, University of California, San Diego, San Diego, United States.
Maria Elena Gentile *Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-9138-1053
Sunyoung LeeDepartment of Pediatrics, University of California, San Diego, San Diego, United States.
Maya E KotasDivision of Pulmonary, Critical Care, Allergy & Sleep Medicine, University of California, San Francisco, San Francisco, United States.
Maria Fernanda de Mello CostaDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.
Nicolas P HolcombDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.
Abigail JaquishDepartment of Pediatrics, University of California, San Diego, San Diego, United States.
Gargi PalashikarDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.
Marcella SoewignjoDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.
Margaret McDanielDepartment of Immunology, University of Washington, Seattle, United States.
Ichiro MatsumotoMonell Chemical Senses Center, Philadelphia, United States.
Robert MargolskeeMonell Chemical Senses Center, Philadelphia, United States.
Jakob Von MoltkeDepartment of Immunology, University of Washington, Seattle, United States.
Noam A CohenMonell Chemical Senses Center, Philadelphia, United States.
Xin SunDivision of Biological Sciences, University of California, San Diego, San Diego, United States.ORCID 0000-0001-8387-4966
Andrew E VaughanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-5740-643X
University of California San Diego · USUniversity of Pennsylvania · USMonell Chemical Senses Center · USCalifornia Institute for Regenerative Medicine · USUniversity of Washington · USUniversity of California, San Francisco · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MMUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6MPathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MDissecting the Interoception Circuit that Controls Airway ConstrictionR01AT011676 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2021 to 2025
$3.8MSolitary chemosensory / tuft cells in lung regeneration and inflammationR01HL153539 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2020 to 2024
$2.0MGenetic Basis of Normal and Pathological Alveologenesis in Lung DevelopmentR01HL142215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2018 to 2021
$2.0MNot all those who wander are lost: Specification of lung innervating sensory neuronsF32HL151168 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARR, JUSTINN · 2020 to 2022
$204kRole of ILC2s in lung maintenance and repairF32HL140868 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOTAS, MAYA · 2018 to 2020
$168kTaste Receptor Genetics, The Sinonasal Microbiome and Chronic RhinosinusitisI01CX001617 · VA · PHILADELPHIA VA MEDICAL CENTER · PI COHEN, NOAM A · 2018 to 2022
–CSRD VA I01 CX001617NCCIH NIH HHS R01 AT011676NHLBI NIH HHS F32 HL140868NHLBI NIH HHS F32 HL151168NHLBI NIH HHS R01 HL142215NHLBI NIH HHS R01 HL153539NHLBI NIH HHS T32 HL007185NIDDK NIH HHS P30 DK019525NIGMS NIH HHS T32 GM133351NINDS NIH HHS P30 NS047101
Abstract
While the lung bears significant regenerative capacity, severe viral pneumonia can chronically impair lung function by triggering dysplastic remodeling. The connection between these enduring changes and chronic disease remains poorly understood. We recently described the emergence of tuft cells within Krt5
Indexed as
CytokinesInfluenza, HumanAnimalsBleomycinGoblet CellsHumansLungMiceBleomycinCytokinesinfluenzalungmouseregenerative medicinestem cellstuft cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.