ArticleBJOG : an international journal of obstetrics and gynaecology2023
Iatrogenic and spontaneous preterm birth in England: A population-based cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Global and population-specific association of MTHFR polymorphisms with preterm birth risk: a consolidated analysis of 44 studies.BMC pregnancy and childbirth · 2025Pooled it
- Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Temporal Patterns in Preterm Birth Subtypes and Perinatal Survival, 2000-2023: Population-Based, Repeated Cross-Sectional Time-Series.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Maternal migraine, vascular comorbidities, and prematurity: exploring overlooked associations in pregnancy.Frontiers in global women's health · 2026Article
- Multi-tissue miRNA networks in preterm birth: from molecular mechanisms to precision medicine.Frontiers in immunology · 2026Review
- Maternal urinary metabolomic signatures preceding spontaneous preterm birth: A pilot study.Scientific reports · 2025Article
- Variation in risk factors and timing of birth for different types of preterm birth: A historical cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Inequalities in Preterm Birth in England: A Retrospective National Cohort Study Focusing on Deprivation and Ethnicity, Using Routinely Collected Maternity Hospital Data.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Individual and combined effects of maternal per- and polyfluoroalkyl substances exposure on preterm birth: a nested case-control study in China.Environmental health : a global access science source · 2025Article
- Perinatal Outcomes of Chronic Abruption Oligohydramnios Sequence: A Multicenter Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Reframing spontaneous preterm birth as a preventable adverse outcome-A clinical audit of a preventative toolbox.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Focussing on the origins of preterm birth: Why understanding aetiology is critical to optimising outcomes.PLoS medicine · 2025Review
- The Contribution of Hypertensive Disorders of Pregnancy to Neonatal Unit Admissions and Iatrogenic Preterm Delivery at < 34BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Article
- Analysis on the prevalence and temporal trends of adverse birth outcomes among neonates in Shanghai from 2010 to 2023.Frontiers in public health · 2025Article
- INSIGHT-2: mechanistic studies into pregnancy complications and their impact on maternal and child health-study protocol.Reproductive health · 2024Article
- Midpregnancy Placental Growth Factor Screening and Early Preterm Birth.JAMA network open · 2024Article
- Small RNAs in the pathogenesis of preeclampsia.Placenta · 2024Review
- Gestational diabetes complicated with preterm birth: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study.The Lancet regional health. Europe · 2024Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo describe the rates of and risk factors associated with iatrogenic and spontaneous preterm birth and the variation in rates between hospitals.
designCohort study using electronic health records.
settingEnglish National Health Service. POPULATION: Singleton births between 1 April 2015 and 31 March 2017.
methodsMultivariable Poisson regression models were used to estimate adjusted risk ratios (adjRR) to measure association with maternal demographic and clinical risk factors.
main outcome measuresPreterm births (<37 weeks of gestation) were defined as iatrogenic or spontaneous according to mode of onset of labour.
resultsOf the births, 6.1% were preterm and of these, 52.8% were iatrogenic. The proportion of preterm births that were iatrogenic increased after 32 weeks. Both sub-groups were associated with previous preterm birth, extremes of maternal age, socio-economic deprivation and smoking. Iatrogenic preterm birth was associated with higher body mass index (BMI) (BMI >40 kg/m
conclusionsJust over half of all preterm births resulted from iatrogenic intervention. Iatrogenic births have overlapping but different patterns of maternal demographic and clinical risk factors to spontaneous preterm births. Iatrogenic and spontaneous sub-groups should therefore be measured and monitored separately, as well as in aggregate, to facilitate different prevention strategies. This is feasible using routinely acquired hospital data.
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