Evidence map›Paper›PMID 36073215›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[FUT8 modulates galectin-3 expression to regulate TGF-β1-mediated fibrosis of lung fibroblasts].

W Gao, D Liu, X Zhang, Q Feng, Y Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

W GaoDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
D LiuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
X ZhangDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Q FengDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Y LiuDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Second Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the regulatory role of

methodsC57/BL6 mice were randomized into 4 groups for treatment with saline (control group), bleomycin, bleomycin+sh-NC or bleomycin+sh-FUT8, and pulmonary fibrosis was observed using Masson staining.MRC-5 cells were transfected with si-NC, FUT8 siRNA (si-FUT8), or both si-FUT8 and a galectin-3(Gal-3) overexpression plasmid (pcDNA3.1-Gal) prior to TGF-β1 treatment, and the changes in cell proliferation and migration were assessed using CCK-8 assay, BrdU assay, and wound healing assay; the changes in the expression levels of

resultsFUT8 knockdown significantly reduced bleomycin-induced extracellular collagen deposition in the lung tissues of the mice.Silencing FUT8 obviously inhibited cell proliferation (

conclusionFUT8 regulates TGF-β1-induced proliferation, migration and fibrosis of MRC-5 cells by modulating Gal-3 expression, in which the FAK/Akt pathway may play a role.

Indexed as

FucosyltransferasesTransforming Growth Factor beta1AnimalsBleomycinFibroblastsFibrosisGalectin 3HumansLungMiceProto-Oncogene Proteins c-aktBleomycinFucosyltransferasesGalectin 3Proto-Oncogene Proteins c-aktTransforming Growth Factor beta1fibrosisFUT8galectin-3migrationproliferation

Identifiers

PMID36073215
PMCPMC9458527
OpenAlexW4294991050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.