ArticleEpigenomics2022
The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment.
Abstract read
In one paragraph
Article in Epigenomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- Epigenetic mechanisms linking the perinatal environment, the placenta, and maternal and child health outcomes: evidence for sexual dimorphism.Environmental epigenetics · 2026Article
- The placenta as a window into neonatal brain injury.Seminars in perinatology · 2025Review
- Placental epigenetic age and adolescent blood pressure: the Extremely Low Gestational Age Newborn cohort.Pediatric research · 2025Article
- Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age.Environmental advances · 2025Article
- Transmembrane Protein 43: Molecular and Pathogenetic Implications in Arrhythmogenic Cardiomyopathy and Various Other Diseases.International journal of molecular sciences · 2025Review
- Maternal-offspring brain and tissue cross-talk in preeclampsia: insights from a rat model.Metabolic brain disease · 2025Article
- Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes.Current environmental health reports · 2024Review
- Article
- A role for adverse childhood experiences and depression in preeclampsia.Journal of clinical and translational science · 2024Article
- Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder.International journal of molecular sciences · 2023Article
- Prenatal Alcohol Exposure Impairs the Placenta-Cortex Transcriptomic Signature, Leading to Dysregulation of Angiogenic Pathways.International journal of molecular sciences · 2023Article
- Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.Clinical epigenetics · 2023Article
- A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm.Autism research : official journal of the International Society for Autism Research · 2023Article
- Expression of placental CD146 is dysregulated by prenatal alcohol exposure and contributes in cortical vasculature development and positioning of vessel-associated oligodendrocytes.Frontiers in cellular neuroscience · 2023Article
- Advancement of epigenetics in stroke.Frontiers in neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Anastasia N FreedmanDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6107-4642
Lauren A EavesDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6056-923X
Julia E RagerDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2882-5042
Noemi Gavino-LopezDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Lisa SmeesterDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5283-0485
Jacqueline BangmaDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-1512-173X
Hudson P SantosInstitute for Environmental Health Solutions, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4040-366X
Robert M JosephDepartment of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-6879-0254
Karl Ck KubanDepartment of Pediatrics, Division of Child Neurology, Boston Medical Center, Boston, MA 02118, USA.
Thomas Michael O'SheaDepartment of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6692-911X
Rebecca C FryDepartment of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-0899-9018
Funding
STOCHASTIC ANALYSIS OF FLOW AND TRANSPORT PHENOMENAP42ES005948 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 1992 to 2017
$45.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MNeonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0MThe Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9MEnvironment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4MPlacental Epigenome and Brain Dysfunction after Preterm BirthR01HD092374 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2017 to 2021
$3.2MIn utero exposure to arsenic, links to epigenetic alterations and diseaseR01ES019315 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 2010 to 2014
$2.3MGenetic and Epigenetic Effects on Childhood Cognitive TrajectoriesR01NR019245 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANTOS, HUDSON · 2020 to 2024
$1.7MPlacental Origins of Positive Child Health OutcomesR03HD101413 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SANTOS, HUDSON · 2020 to 2021
$149kACL HHS T42OH008673NICHD NIH HHS R01 HD092374NICHD NIH HHS R03 HD101413NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES005948NIEHS NIH HHS R01 ES019315NIH HHS UG3 OD023348NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069NINR NIH HHS R01 NR019245
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cognitive DysfunctionMicroRNAsAdolescentBrainChildEpigenomeEpigenomicsFemaleHumansPlacentaPregnancyTranscriptomeMicroRNAscognitionepigeneticsepigenomemiRNAmRNAplacenta
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.