Evidence map›Paper›PMID 36073059›Full record

ArticlePhysiological reports2022

Tromethamine improves mucociliary clearance in cystic fibrosis pigs.

Jamison J Ash, Brieanna M Hilkin, Nicholas D Gansemer, Eric A Hoffman, Joseph Zabner, David A Stoltz, Mahmoud H Abou Alaiwa

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mucociliary clearance is impaired in small airways of cystic fibrosis pigs.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  2. European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jamison J AshDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Brieanna M HilkinDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Nicholas D GansemerDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Eric A HoffmanDepartment of Radiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Joseph ZabnerDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-9606-1339
David A StoltzDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-0893-9015
Mahmoud H Abou AlaiwaDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0003-4525-0217
University of Iowa · US

Funding

Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Airway Alkalinization and Repurposing Tromethamine as a Therapeutic Approach in Cystic FibrosisR01HL136813 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A, ZABNER, JOSEPH · 2017 to 2021
$5.3M
Mechanisms of impaired mucociliary transport in CF airway diseaseK08HL135433 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2017 to 2021
$801k
Mechanism for Hypertonic Saline Effect on Mucociliary TransportR56HL147073 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2020 to 2020
$465k
NHLBI NIH HHS K08 HL135433NHLBI NIH HHS NIH PPG HL051670NHLBI NIH HHS NIH PPG HL091842NHLBI NIH HHS NIH R01 HL136813NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R01 HL136813NHLBI NIH HHS R56 HL147073NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl

Indexed as

Cystic FibrosisAnimalsBicarbonatesMucociliary ClearanceRespiratory MucosaSwineTromethamineBicarbonatesTromethamineCT imagingcystic fibrosismucociliary transporttherapeutics

Identifiers

PMID36073059
PMCPMC9453173
OpenAlexW4294991475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.