Evidence map›Paper›PMID 36073014›Full record

ArticleBJPsych open2022

Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial.

Nicholas Cheng, Alison McLaverty, Barnaby Nelson, Connie Markulev, Miriam R Schäfer, Maximus Berger, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B Hickie and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Schizophrenia bulletin open · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 9 countries.

Nicholas ChengOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.ORCID https://orcid.org/0000-0003-2209-4717
Alison McLavertyMelbourne School of Psychological Sciences, The University of Melbourne, Australia.
Barnaby NelsonOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.ORCID https://orcid.org/0000-0002-6263-2332
Connie MarkulevOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Miriam R SchäferOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Maximus BergerOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia; and Department of Psychiatry and Psychotherapy, University of Bern, Switzerland.
Nilufar MossahebDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Austria.
Monika SchlögelhoferBioPsyC Biopsychosocial Corporation, Vienna, Austria.
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
Ian B HickieBrain and Mind Centre, The University of Sydney, Australia.
Gregor E BergerChild and Adolescent Psychiatric Service, Canton of Zurich, Switzerland.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Hong Kong.
Lieuwe de HaanDepartment of Psychiatry, Academic Medical Center, The Netherlands.
Dorien H NiemanDepartment of Psychiatry, Academic Medical Center, The Netherlands.
Merete NordentoftMental Health Centre Copenhagen, Department of Clinical Medicine, Copenhagen University Hospital, Denmark.
Anita Riecher-RösslerFaculty of Medicine, University of Basel, Switzerland.
Swapna VermaEarly Psychosis Intervention, Institute of Mental Health, Singapore.
Rebekah StreetOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Andrew ThompsonOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Hok Pan YuenOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Robert HesterMelbourne School of Psychological Sciences, The University of Melbourne, Australia.
Alison Ruth YungInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Australia; and School of Health Sciences, University of Manchester, UK.ORCID https://orcid.org/0000-0002-0401-9791
Patrick D McGorryOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
Kelly AllottOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia; and Melbourne School of Psychological Sciences, The University of Melbourne, Australia.ORCID https://orcid.org/0000-0002-0640-4634
G Paul AmmingerOrygen, Centre for Youth Mental Health, The University of Melbourne, Australia.
The University of Melbourne · AUAmsterdam UMC Location University of Amsterdam · NLCopenhagen University Hospital · DKDeakin University · AUInstitute of Mental Health · SGJena University Hospital · DEMedical University of Vienna · ATThe University of Sydney · AUUniversity of Basel · CHUniversity of Bern · CHUniversity of Hong Kong · HK

Funding

National Health and Medical Research Council Australia Program (566529)National Health and Medical Research Council Career Development Fellowship (1027532)National Health and Medical Research Council Career Development Fellowship (1141207)National Health and Medical Research Council Senior Principal Research Fellowship (1060996)National Health and Medical Research Council Senior Research Fellowship (1080963)National Health and Medical Research Council Senior Research Fellowship (566593)Stanley Medical Research Institute 07TGF-1102University of Melbourne Dame Kate Campbell Fellowship
6 · The paper itself

Abstract

backgroundCognitive impairments are well-established features of psychotic disorders and are present when individuals are at ultra-high risk for psychosis. However, few interventions target cognitive functioning in this population.

aimsTo investigate whether omega-3 polyunsaturated fatty acid (

methodData (

resultsThe placebo group showed a modest greater improvement over time than the omega-3 supplementation group for motor speed (

conclusionsWe found no evidence to support the use of omega-3 supplementation to improve cognitive functioning in ultra-high risk individuals. The biomarker analysis suggests that this finding is unlikely to be attributed to poor adherence or consumption of non-trial

Indexed as

clinical high riskCognitionearly interventionpsychotic disordersrandomised controlled trial

Identifiers

PMID36073014
PMCPMC9534907
OpenAlexW4294991243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.