ReviewFrontiers in medicine2022
Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression.
Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Are Altered Knee Joint Biomechanics Associated with Future Post-Traumatic Osteoarthritis Outcomes? A Systematic Review and Meta-Analysis of Longitudinal Studies.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Meta-analysis of the value of dual-energy computed tomography in the diagnosis of anterior cruciate ligament injuries of the knee.BMC musculoskeletal disorders · 2024Pooled it
- Osteoarthritis Development Following Meniscectomy vs. Meniscal Repair for Posterior Medial Meniscus Injuries: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Exosome-Laden Scaffolds for Treatment of Post-Traumatic Cartilage Injury and Osteoarthritis of the Knee: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Super-acute massive osteolysis of the femoral head after acetabular fracture fixation : a comparative study with conventional post-traumatic osteonecrosis requiring total hip arthroplasty.Bone & joint open · 2026Article
- Novel Biomaterial-Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis-Driven Osteoarthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Data-Driven Characterization of Knee Structures Using Non-Negative Matrix Factorization of 3D Multi-Echo UTE MRI.NMR in biomedicine · 2026Article
- Targeting E3 Ubiquitin Ligases in Post-Traumatic Osteoarthritis: Therapeutic Opportunities and Pharmacological Perspectives.Pharmaceutics · 2026Review
- Cellular and molecular landscapes of inflammation in anterior cruciate ligament rupture patients are independent on concurrent meniscal injury.Arthritis research & therapy · 2026Article
- MRI of Knee Joint Lesions: An Observational Study of Traumatic, Degenerative, Cystic, and Neoplastic Pathologies.Cureus · 2026Article
- outcomes of acute total hip arthroplasty (THA) in the management of acetabular fractures: a case series.Orthopedic reviews · 2026Article
- Long-term impact of acute knee injury with hemarthrosis: Osteoarthritis incidence and patient-reported outcomes in a large consecutive cohort over 12 years.Osteoarthritis and cartilage open · 2025Article
- Superb microvascular imaging in the assessment of persistent synovitis after anterior cruciate ligament reconstruction.Osteoarthritis imaging · 2025Article
- Feasibility study of the Cambridge knee injury tool (CamKIT): 18-month analysis of acute knee injuries at an urgent treatment centre.Journal of clinical orthopaedics and trauma · 2025Article
- Dual-center study on AI-driven multi-label deep learning for X-ray screening of knee abnormalities.Scientific reports · 2025Article
- Impact of infrapatellar fat pad injury severity on subsequent patellofemoral cartilage degeneration following acute ACL tear.Journal of orthopaedics · 2025Article
- Informing a Clinical Pathway for Acute Knee Injuries: Survey Insights From Rural Clinicians.The Australian journal of rural health · 2025Article
- Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway.Journal of orthopaedic translation · 2025Article
- Patellofemoral Cartilage Degradation Based on T1ρ Relaxation Times Varies Inversely With BMI After Patellar Dislocation.Orthopaedic journal of sports medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee injuries such as anterior cruciate ligament ruptures and meniscal injury are common and are most frequently sustained by young and active individuals. Knee injuries will lead to post-traumatic osteoarthritis (PTOA) in 25-50% of patients. Mechanical processes where historically believed to cause cartilage breakdown in PTOA patients. But there is increasing evidence suggesting a key role for inflammation in PTOA development. Inflammation in PTOA might be aggravated by hemarthrosis which frequently occurs in injured knees. Whereas mechanical symptoms (joint instability and locking of the knee) can be successfully treated by surgery, there still is an unmet need for anti-inflammatory therapies that prevent PTOA progression. In order to develop anti-inflammatory therapies for PTOA, more knowledge about the exact pathophysiological mechanisms and exact course of post-traumatic inflammation is needed to determine possible targets and timing of future therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.