Evidence map›Paper›PMID 36072646›Full record

ArticleBrain communications2022

Astrogliosis in aging and Parkinson's disease dementia: a new clinical study with

Mohamed A Mohamed, Zhou Zeng, Marta Gennaro, Nicholas P Lao-Kaim, Jim F M Myers, Valeria Calsolaro, Grazia Daniela Femminella, Robin J Tyacke, Antonio Martin-Bastida, Roger N Gunn and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Imaging the interaction of astrocytes and neurons.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  12. Imidazoline-I2 PET Tracers in Neuroimaging.International journal of molecular sciences · 2023
    Review
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 4 countries.

Mohamed A MohamedDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-8919-3667
Zhou ZengDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-3298-3481
Marta GennaroDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Nicholas P Lao-KaimDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Jim F M MyersDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Valeria CalsolaroDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Grazia Daniela FemminellaDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Robin J TyackeDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Antonio Martin-BastidaDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Roger N GunnDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
David J NuttDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Paul EdisonDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-6551-2002
Paola PicciniDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0003-4162-6141
Andreas-Antonios RoussakisDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0001-5748-6978
Hammersmith Hospital · GBCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use

Indexed as

agingastrogliosisimidazoline binding sitesParkinson’s disease dementiaPET

Identifiers

PMID36072646
PMCPMC9445175
OpenAlexW4292411604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.