Evidence map›Paper›PMID 36072534›Full record

ArticleTranslational pediatrics2022

A juvenile murine model with chronic lung inflammation induced by repeated intratracheal instillation of lipopolysaccharides: a versatile and replicable model.

Kailin Mai, Xiaowen Chen, Kangkang Zhang, Shujun Gu, Xiao Wu, Zihao Gu, Zhongji Wu, Kaiyin Huang, Zhenwei Liu, Zifeng Yang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kailin MaiDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaowen ChenDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kangkang ZhangDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shujun GuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiao WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zihao GuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhongji WuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kaiyin HuangDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhenwei LiuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zifeng YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dehui ChenDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recurrent lower respiratory tract infection or chronic pulmonary infection often occur in children with chronic lung diseases (CLDs). By continuous lung inflammation, recurrent and chronic infection could cause irreversible airway structural and lung function damage, which eventually leads to respiratory failure and death. Methods: In purpose of recapitulating persistent high-intensity lung inflammation caused by recurrent lower respiratory tract infection or chronic infection, we established a juvenile murine model with chronic lung inflammation induced by repeated intratracheal instillations of lipopolysaccharides (LPS) from Results: All mice in LPS Conclusions: Intratracheal instillation of 0.5 mg/kg LPS once a week for 4 weeks can cause chronic lung inflammation in young mice.

Indexed as

Chronic lung inflammationintratracheal instillationjuvenile murine models

Identifiers

PMID36072534
PMCPMC9442212
OpenAlexW4286662576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.