Evidence map›Paper›PMID 36072506›Full record

ArticleNational science review2022

The allosteric gating mechanism of the MthK channel.

Fenghui Guan, Tianyu Li, Wei Dong, Rui Guo, Hao Chai, Zhiqiu Chen, Zhong Ren, Yang Li, Sheng Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fenghui GuanFrontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, China.
Tianyu LiState Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wei DongLife Sciences Institute, Zhejiang University, Hangzhou 310058, China.
Rui GuoDepartment of Logistics, Tianjin University, Tianjin 300072, China.
Hao ChaiState Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhiqiu ChenUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Zhong RenDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Yang LiState Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Sheng YeFrontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, China.ORCID https://orcid.org/0000-0001-9300-6257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allostery is a fundamental element during channel gating in response to an appropriate stimulus by which events occurring at one site are transmitted to distal sites to regulate activity. To address how binding of the first Ca

Indexed as

allosteric gating mechanismion channelprotein structural data analysis

Identifiers

PMID36072506
PMCPMC9440719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.