Evidence map›Paper›PMID 36072013›Full record

SynthesisGenetics research2022

Association of

Hongfeng Yan, Fuquan Jiang, Jianwu Yang

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Genetics research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hongfeng YanDepartment of General Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing 100101, China.
Fuquan JiangDepartment of General Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing 100101, China.ORCID 0000-0002-8628-5339
Jianwu YangDepartment of General Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing 100101, China.ORCID 0000-0002-8109-8024
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Accumulating evidence indicates that the expression and/or variants of several genes play an essential role in the progress of colorectal cancer (CRC). The current study is a meta-analysis undertaken to estimate the prognosis and survival associated with Methods: The authors searched PubMed, EMBASE, and Science Direct for relevant reports published between 2000 and 2020 and analyzed them to determine any relationship between the (immunohistochemically/sequencing-detected) gene expression and variants of the selected genes and the survival of CRC patients. Results: The analysis included 34,074 patients from 64 studies. To evaluate association, hazard ratios (HRs) were estimated for overall survival (OS) or disease-free survival (DFS), with a 95% confidence interval (CIs). Pooled results showed that Conclusions: The present meta-analysis indicates that overexpression or underexpression and variants of

Indexed as

beta CateninColorectal NeoplasmsCyclin D1Genes, bcl-1HumansPrognosisSmad3 ProteinTumor Suppressor Protein p53beta CateninCyclin D1Smad3 ProteinSMAD3 protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID36072013
PMCPMC9402361
OpenAlexW4292343608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.