Evidence map›Paper›PMID 36071926›Full record

ReviewNeuro-oncology advances

Identifying clinically applicable machine learning algorithms for glioma segmentation: recent advances and discoveries.

Niklas Tillmanns, Avery E Lum, Gabriel Cassinelli, Sara Merkaj, Tej Verma, Tal Zeevi, Lawrence Staib, Harry Subramanian, Ryan C Bahar, Waverly Brim and 13 more

Open access · goldAbstract readReview
In one paragraph

Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Niklas TillmannsBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-9366-7183
Avery E LumBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Gabriel CassinelliBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Sara MerkajBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Tej VermaBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Tal ZeeviBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Lawrence StaibBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Harry SubramanianBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Ryan C BaharBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Waverly BrimBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Jan LostBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Leon JekelBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Alexandria BrackettHarvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, Connecticut, USA.
Sam PayabvashBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Ichiro IkutaBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
MingDe LinBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Khaled BousabarahVisage Imaging, GmbH, Berlin, Germany.
Michele H JohnsonBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Jin CuiDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA.
Ajay MalhotraBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-9223-6640
Antonio OmuroDepartment of Neurology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA.
Bernd TurowskiUniversity Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, Germany.
Mariam S AboianBrain Tumor Research Group, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-4877-8271
Heinrich Heine University Düsseldorf · DEBoston Children's Hospital · USYale Cancer Center · USYale University · US

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver CancerR01CA206180 · NCI · YALE UNIVERSITY · PI CHAPIRO, JULIUS, DUNCAN, JAMES S · 2016 to 2025
$6.1M
Short Term Research Training: Students in Health Professional SchoolsT35DK104689 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY, Sarwat I Chaudhry · 2015 to 2026
$2.6M
Radiomics Signatures and Patient Outcomes in Intracerebral HemorrhageK23NS118056 · NINDS · YALE UNIVERSITY · PI Seyedmehdi Payabvash · 2021 to 2026
$780k
NCATS NIH HHS KL2 TR001862NCI NIH HHS R01 CA206180NIDDK NIH HHS T35 DK104689NINDS NIH HHS K23 NS118056
6 · The paper itself

Abstract

Background: While there are innumerable machine learning (ML) research algorithms used for segmentation of gliomas, there is yet to be a US FDA cleared product. The aim of this study is to explore the systemic limitations of research algorithms that have prevented translation from concept to product by a review of the current research literature. Methods: We performed a systematic literature review on 4 databases. Of 11 727 articles, 58 articles met the inclusion criteria and were used for data extraction and screening using TRIPOD. Results: We found that while many articles were published on ML-based glioma segmentation and report high accuracy results, there were substantial limitations in the methods and results portions of the papers that result in difficulty reproducing the methods and translation into clinical practice. Conclusions: In addition, we identified that more than a third of the articles used the same publicly available BRaTS and TCIA datasets and are responsible for the majority of patient data on which ML algorithms were trained, which leads to limited generalizability and potential for overfitting and bias.

Indexed as

artificial intelligencegliomamachine learningsegmentation

Identifiers

PMID36071926
PMCPMC9446682
OpenAlexW4282933722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.