Evidence map›Paper›PMID 36071808›Full record

ArticleIUCrJ2022

Higher resolution in cryo-EM by the combination of macromolecular prior knowledge and image-processing tools.

Erney Ramírez-Aportela, Jose M Carazo, Carlos Oscar S Sorzano

Abstract read
In one paragraph

Article in IUCrJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Factors affecting macromolecule orientations in thin films formed in cryo-EM.Acta crystallographica. Section D, Structural biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erney Ramírez-AportelaBiocomputing Unit, National Centre for Biotechnology (CNB CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain.
Jose M CarazoBiocomputing Unit, National Centre for Biotechnology (CNB CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain.
Carlos Oscar S SorzanoBiocomputing Unit, National Centre for Biotechnology (CNB CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-particle cryo-electron microscopy has become a powerful technique for the 3D structure determination of biological molecules. The last decade has seen an astonishing development of both hardware and software, and an exponential growth of new structures obtained at medium-high resolution. However, the knowledge accumulated in this field over the years has hardly been utilized as feedback in the reconstruction of new structures. In this context, this article explores the use of the deep-learning approach

Indexed as

cryo-electron microscopydeepEMhancerdeep learningprior knowledgeRELION

Identifiers

PMID36071808
PMCPMC9438491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.