Evidence map›Paper›PMID 36071755›Full record

ArticleJournal of thoracic disease2022

Dynamic evaluation of the pulmonary protective effects of prone position ventilation via respiratory mechanics for patients with moderate to severe acute respiratory distress syndrome.

Zhenjie Jiang, Zhe Zhang, Qingwen Sun, Baozhu Zhang, Qiuxue Deng, Yin Xi, Weiqun He, Xiaoqing Liu, Yuanda Xu, Tao Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. [Mitochondrial adaptations in acute respiratory distress syndrome].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhenjie Jiang *State Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhe Zhang *State Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qingwen Sun *State Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Baozhu ZhangState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qiuxue DengState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yin XiState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Weiqun HeState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoqing LiuState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yuanda XuState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Tao ChenState Key Laboratory of Respiratory Disease, Department of Critical Care Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, National Center of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with moderate to severe acute respiratory distress syndrome (ARDS) have been recommended to receive prone position ventilation (PPV). However, the dynamic changes in respiratory mechanics during PPV and their relationship with the prognosis have not been sufficiently evaluated. In addition, the impact of using neuromuscular blocking agents (NMBAs) during PPV on respiratory mechanics is not clear enough. Thus, the study aims to investigate the above-mentioned issues. Methods: A prospective cohort study was conducted on 22 patients with moderate to severe ARDS who received PPV in the intensive care unit (ICU) of the First Affiliated Hospital of Guangzhou Medical University. A multifunctional gastric tube was used to measure the patients' respiratory mechanics during supine position ventilation (SPV), early PPV (PPV within 4 h of initiation), and middle/late PPV (more than 6 h after the initiation of PPV). Longitudinal data were analyzed with generalized estimating equations (GEE). Results: Compared with SPV, the esophageal pressure swings (ΔPes) measured during the PPV was significantly higher (SPV 7.46 Conclusions: During the transition from SPV to early PPV and then to middle/late PPV, the ΔPes in the PPV were greater than SPV and it fluctuated within a normal range while oxygenation improved significantly in all patients. The Ppeak, ΔPes and RR in the death group were significantly higher than survival group. When NMBAs were used, the ΔPes, inspiratory transpulmonary pressure (PLei), driving pressure (DP) and DPL were significantly decreased, suggesting that the rational combination of NMBAs and PPV may exert a synergistic protective effect on the lungs.

Indexed as

acute respiratory distress syndrome (ARDS)lung protective ventilationProne position ventilation (PPV)respiratory mechanics

Identifiers

PMID36071755
PMCPMC9442532
OpenAlexW4290465752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.