Evidence map›Paper›PMID 36071645›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI.

Hannah L Chandler, Rachael C Stickland, Eleonora Patitucci, Michael Germuska, Antonio M Chiarelli, Catherine Foster, Shona Bhome-Dhaliwal, Thomas M Lancaster, Neeraj Saxena, Sharmila Khot and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Age-related decline in cerebral oxygen consumption in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Hannah L ChandlerCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Rachael C SticklandCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.ORCID 0000-0003-3398-4272
Eleonora PatitucciCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Michael GermuskaCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.ORCID 0000-0003-0580-4350
Antonio M ChiarelliInstitute for Advanced Biomedical Technologies, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.ORCID 0000-0002-5347-8417
Catherine FosterCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Shona Bhome-DhaliwalCardiff University School of Medicine, Cardiff, UK.
Thomas M LancasterCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Neeraj SaxenaCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Sharmila KhotCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Valentina TomassiniCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Richard G WiseCUBRIC, School of Psychology, Cardiff University, Cardiff, UK.
Cardiff University · GBUniversity of Chieti-Pescara · ITCwm Taf University Health Board · GBNorthwestern University · USUniversity Hospital of Wales · GBUniversity of Bath · GBWales Institute of Social and Economic Research, Data and Methods · GB

Funding

Wellcome TrustWellcome Trust 104943/Z/14/ZWellcome Trust 220575/Z/20/Z
6 · The paper itself

Abstract

Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify energy utilisation and mitochondrial function in the human brain. Here, we used novel dual-calibrated functional magnetic resonance imaging (dc-fMRI) to map grey-matter (GM) deoxy-haemoglobin sensitive cerebral blood volume (CBV

Indexed as

Multiple SclerosisBrainHumansMagnetic Resonance ImagingOxygenOxygencerebral blood flowcerebral oxygen consumptiondisabilityMultiple sclerosisneurodegeneration

Identifiers

PMID36071645
PMCPMC9875355
OpenAlexW4294939527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.