ArticleScandinavian journal of public health2024
Marital status and genetic liability independently predict coronary heart disease incidence.
Article in Scandinavian journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Patterns among factors associated with myocardial infarction: chi-squared automatic interaction detection tree and binary logit model.BMC public health · 2025Article
- Meta-analysis of the association between marital status and cardiovascular diseases.JRSM cardiovascular diseaseReview
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Authors and funding
7 authors at 3 institutions in 5 countries.
Funding
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Abstract
aimsMarried individuals have a lower coronary heart disease (CHD) risk than non-married, but the mechanisms behind this are not fully understood. We analyzed whether genetic liability to CHD may affect these associations.
methodsMarital status, a polygenic score of CHD (PGS-CHD), and other risk factors for CHD were measured from 35,444 participants (53% female) in Finnish population-based surveys conducted between 1992 and 2012. During the register-based follow-up until 2020, there were 2439 fatal and non-fatal incident CHD cases. The data were analyzed using linear and Cox regression models.
resultsDivorced and cohabiting men and women had a higher genetic risk of CHD than married individuals, but the difference was very small (0.023-0.058 standard deviation of PGS-CHD,
conclusionsWe showed minor differences between the marital status categories in PGS-CHD and demonstrated that marital status and genetic liability predicted CHD incidence largely independently. This emphasizes the need to measure multiple risk factors when predicting CHD risk.
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