Evidence map›Paper›PMID 36071597›Full record

SynthesisPediatric pulmonology2022

Respiratory infections in children born preterm in low and middle-income countries: A systematic review.

Shivashankar Diggikar, Abhishek Paul, Abdul Razak, Manigandan Chandrasekaran, Ravi Shankar Swamy

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Pediatric pulmonology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Shivashankar DiggikarDepartment of Pediatrics, Oyster Woman and Child Speciality Hospital, Bengaluru, India.ORCID 0000-0002-6259-3118
Abhishek PaulDepartment of Pediatrics, Manipal Hospitals, Whitefield, Bengaluru, India.
Abdul RazakDepartment of Pediatrics, Monash University, Victoria, Australia.ORCID 0000-0002-6185-3694
Manigandan ChandrasekaranDepartment of Neonatology, Liverpool Women's Hospital NHS Foundation Trust, Liverpool, UK.
Ravi Shankar SwamyDepartment of Pediatrics, Manipal Hospitals, Whitefield, Bengaluru, India.
Imperial College Healthcare NHS Trust · GBManipal Hospital · INOyster Hospital · INPrincess Nourah bint Abdulrahman University · SAUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextStudies from high-income countries indicates that infants born preterm are at increased risk of respiratory infections; however in the low and middle-income countries (LMICs) data are limited. Our aim was to systematically review the studies evaluating the risk of respiratory infections in preterm children born in LMICs.

methodsWe searched Medline, PubMed, Cumulative Index of Nursing and Allied Health Literature, Embase, and Psych-INFO databases for studies reporting respiratory outcomes in children born preterm in LMICs. Two authors extracted the data and evaluated the risk of bias with appropriate assessment methods independently.

resultsTwelve observational studies evaluating 5969 children were included in the review. The risk of lower respiratory tract infection varied from 5% to 73.9%. Similarly, respiratory syncytial virus (RSV) infection risk ranged from 4.4% to 22.7%. The unadjusted relative risk for any respiratory tract infection or lower respiratory tract infection was significantly higher in the children born preterm than in children born at term (1.52 [95% confidence interval 1.25-1.85]). We also noted wide-ranging risk of respiratory infections requiring in-hospital or emergency care (range: 0.5%-27.7%) and hospital stay in children born preterm (range: 6-14.3 days).

conclusionsPreterm-born children in LMICs are at risk of increased respiratory infections compared to term-born children; however, the baseline risk is variable, although substantial; This highlights the need for preventive strategies, including RSV immunoprophylaxis.

Indexed as

Respiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChildDeveloping CountriesHospitalizationHumansInfantInfant, NewbornLength of StayPovertybronchiolitislow birth weightLRTIpneumoniaprematurerespiratory syncytial virusventilation

Identifiers

PMID36071597
PMCPMC9825919
OpenAlexW4294991442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.