Evidence map›Paper›PMID 36071526›Full record

ArticleJournal of cardiothoracic surgery2022

Predictors of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg.

Ayman R Abdelrehim, Mustafa Al-Muhaya, Alassal A Alkodami, Luna S Baangood, Mansour Al-Mutairi, Abdul Quadeer, Fath A Alabsi, M Alashwal, Mohamed Mofeed F Morsy, Abdulhameed A Alnajjar and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Ayman R AbdelrehimPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia. ayman_elmeghawry@yahoo.com.ORCID http://orcid.org/0000-0002-1947-2839
Mustafa Al-MuhayaPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0003-3170-1574
Alassal A AlkodamiPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0003-1738-4154
Luna S BaangoodPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0002-0134-6244
Mansour Al-MutairiPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0002-4682-9303
Abdul QuadeerPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0001-5104-6517
Fath A AlabsiPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.
M AlashwalPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0001-9897-1574
Mohamed Mofeed F MorsyPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0002-8905-0148
Abdulhameed A AlnajjarPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0002-7120-7813
Sherif S SalemPediatric Cardiac Services, Madinah Cardiac Center MCC, Madinah, Saudi Arabia.ORCID http://orcid.org/0000-0002-4254-4204
Islamic University of Madinah · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVentricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure.

aimThe aim of this study was to determine the risk factors and the predictors of major adverse events (MAEs) and complications following surgical closure of VSD in children weighing less than 10 kg.

methodsThis retrospective cohort study included children less than 10 kg who underwent surgical closure of congenital VSD of any type with or without associated congenital heart diseases. Patients with associated major cardiac anomalies were excluded. Preoperative, operative and postoperative data were collected from medical records.

resultsThis study included 127 patients 52.8% were males, the median age was 8.0 months (IQR = 6.0-11.0 months), and their median weight was 5.7 kg (IQR = 4.8-7.0). Mortality was in one patient (0.8%) Multivariable logistic regression analysis revealed that male sex group (observational data), previous pulmonary artery banding (PAB), and significant intraoperative residual VSD were significant risk factors for the development of MAEs (odds ratios were 3.398, 14.282, and 8.634, respectively). Trisomy 21 syndrome (odds ratio: 5.678) contributed significantly to prolonged ventilation. Pulmonary artery banding (odds ratio: 14.415), significant intraoperative (3 mm) residual VSD (odds ratio: 11.262), and long cross-clamp time (odds ratio: 1.064) were significant predictors of prolonged ICU stay, whereas prolonged hospital stay was observed significantly in male sex group (odds ratio: 12.8281), PAB (odds ratio: 2.669), and significant intraoperative (3 mm) residual VSD (odds ratio: 19.551).

conclusionsSurgical VSD repair is considered a safe procedure with very low mortality. Trisomy 21 was a significant risk factor for prolonged ventilation. Further, PAB, significant intraoperative residual of 3 mm or more that required a second pulmonary bypass, and a greater cross-clamp time were significant predictors of MAE and associated complications with prolonged ICU and hospital stay.

Indexed as

Down SyndromeHeart Septal Defects, VentricularChildFemaleHumansInfantLength of StayMaleRetrospective StudiesRisk FactorsMajor adverse eventsSurgical closureVentricular septal defect

Identifiers

PMID36071526
PMCPMC9450295
OpenAlexW4294991689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.