ArticleAnnals of clinical microbiology and antimicrobials2022
Next-generation sequencing-assisted diagnosis of a case of leprosy misdiagnosed as erythema multiforme.
Article in Annals of clinical microbiology and antimicrobials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Plasma irisin levels in newly diagnosed leprosy patients: a case-control study.Archives of dermatological research · 2025Article
- Misdiagnosis of leprosy: An underappreciated reason for its continued prevalence.The Indian journal of medical research · 2025Article
- Case Report: A case of borderline lepromatous leprosy and literature review-key clues to expand clinical diagnostic thinking.Frontiers in medicine · 2025Article
- Knowledge and Skills of Leprosy Among Healthcare Workers and Its Associated Factors in Primary Healthcare.Inquiry : a journal of medical care organization, provision and financingArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae or Mycobacterium lepromatosis that is mainly transmitted through droplets from the nose and mouth of untreated patients. Owing to the lack of specific serological markers and clinical manifestations, leprosy can be easily confused with other skin lesion-related diseases and is difficult to distinguish. CASE PRESENTATION: This study introduces and summarises the diagnosis and treatment process of a case of leprosy misdiagnosed as erythema multiforme for a long time. A 43-year-old female was admitted to our hospital because of "repeated fever with superficial lymphadenopathy and systemic rash in May". The diagnosis of the patient was based on the two main clinical characteristics of superficial lymphadenopathy and systemic pleomorphic erythema by using a combination of multiple samples of lymph nodes and skin, routine pathological examination, immunohistochemistry, acid-fast, silver hexamine, periodic acid-Schiff (PAS) staining, and second-generation gene sequencing of fresh biopsy tissue. The patient was treated with dapsone, rifampicin, and clofazimine at the Institute of Dermatology and Venereal Diseases. After treatment for 1 year, her temperature returned to normal, the area of facial erythema decreased, and the volume of axillary lymph nodes had gradually reduced.
conclusionsIn conclusion, special pathological staining and second-generation gene sequencing show promising advantages in distinguishing leprosy from other skin lesion-related diseases.
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