Evidence map›Paper›PMID 36071488›Full record

ReviewCancer cell international2022

Camels' biological fluids contained nanobodies: promising avenue in cancer therapy.

Nouf S Al-Numair, Abdulrahman Theyab, Faisal Alzahrani, Anwar M Shams, Ibrahim O Al-Anazi, Atif Abdulwahab A Oyouni, Osama M Al-Amer, Charalampos Mavromatis, Islam M Saadeldin, Wed A Abdali and 1 more

Erratum issuedAbstract readReview
In one paragraph

Review in Cancer cell international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nouf S Al-NumairCenter of Genomic Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Abdulrahman TheyabDepartment of Laboratory & Blood Bank, Security Forces Hospital, P.O. Box 14799, Mecca, 21955, Saudi Arabia.
Faisal AlzahraniDepartment of Biochemistry, Faculty of Science, Embryonic Stem Cells Unit, King Fahad Medical Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Anwar M ShamsDepartment of Pharmacology, College of Medicine, Taif University, P.O. BOX 11099, Taif, 21944, Saudi Arabia.
Ibrahim O Al-AnaziThe National Center for Genomic Technology, King Abdulaziz City for Science and Technology, P.O Box 6086, Riyadh, 11442, Saudi Arabia.
Atif Abdulwahab A OyouniDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Osama M Al-AmerDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Charalampos MavromatisDepartment of Biological Sciences, Faculty of Science and Arts (Rabigh Campus), King Abdulaziz University, Jeddah, Saudi Arabia.
Islam M SaadeldinResearch Institute of Veterinary Medicine, Chungam National University, Daejeon, 34134, Korea.
Wed A AbdaliDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Yousef M HawsawiCollege of Medicine, Alfaisal University, P.O. Box 50927, Riyadh, 11533, Saudi Arabia. hyousef@kfshrc.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels' biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.

Indexed as

And nano proteomicsArabian camelidBiological fluidsCancersDiagnosisNanobodiesTherapeutic agents

Identifiers

PMID36071488
PMCPMC9449263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.