Evidence map›Paper›PMID 36071381›Full record

ArticleBMC infectious diseases2022

Epidemiology of early infections and predictors of mortality after autologous hematopoietic stem-cell transplantation among multiple myeloma, Hodgkin, and non-Hodgkin lymphoma: the first experience from Palestine.

Riad Amer, Husam Salameh, Sultan Mosleh, Adham Abu-Taha, Hamza Hamayel, Ahmad Enaya, Amro Adas, Ahmad Khursani, Mohamad Wild-Ali, Taghreed Mousa and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Infection-related mortality after hematopoietic stem cell transplantation in a high antimicrobial resistance setting.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Riad AmerDepartment of Medicine, An-Najah National University Hospital, P.O. Box 7, Nablus, Palestine. riadamer@najah.edu.
Husam SalamehDepartment of Medicine, An-Najah National University Hospital, P.O. Box 7, Nablus, Palestine. husam.salameh@najah.edu.
Sultan MoslehDepartment of Medicine, An-Najah National University Hospital, P.O. Box 7, Nablus, Palestine.
Adham Abu-TahaDepartment of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Hamza HamayelInternal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Ahmad EnayaInternal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Amro AdasInternal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Ahmad KhursaniHematology and Oncology, An-Najah National University Hospital, Nablus, Palestine.
Mohamad Wild-AliHematology and Oncology, An-Najah National University Hospital, Nablus, Palestine.
Taghreed MousaHematology and Oncology, An-Najah National University Hospital, Nablus, Palestine.
Maher BattatHematology and Oncology, An-Najah National University Hospital, Nablus, Palestine.
Aiman DaifallahInternal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Amer KoniInternal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Ramzi ShawahnaDepartment of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
An-Najah National University · PSNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous hematopoietic stem-cell transplantation (HSCT) is the standard of care in many relapsed and refractory lymphoid malignancy, neuroblastoma, and multiple myeloma (MM). This study was conducted to describe the epidemiology of early infections that occurred within the first 100 days among patients who received HSCT for MM, Hodgkin (HL), and non-Hodgkin lymphoma (NHL) in Palestine.

methodsThis study was conducted in a retrospective cohort design in the only autologous HSCT in Palestine in the period between 2014 and 2021. The medical records of the patients were reviewed to identify and collect demographic, clinical, and microbiological data on bacterial, viral, fungal, and parasitic infections as diagnosed by cultures, polymerase chain reaction, and fluorescent antibody testing.

resultsA total of 145 patients were included in this study (median age = 44.0 [28.0, 53.5] years). Of those, 8 (5.5%) were younger than 18 years, 69 (47.6%) had MM, 53 (36.6%) had HL, and 23 (15.9%) had NHL. The source of fever had no focus in the majority of the cases 82 (56.6%), 12 (8.3%) had bloodstream infections, 8 (5.5%) had colitis, and 7.6 (5.0%) had pneumonia. Patients from whom gram-negative bacteria were isolated stayed in the hospital for longer duration compared to the other patients (median = 21.0 [19.0, 25.0] vs. 18.0 [15.0, 22.0] days, p-value = 0.043, respectively). The cumulative incidence of death in the first 100 days after infusion of stem cells was 3.4%. The cumulative incidence of death in the first 100 days post-transplantation was higher for patients with NHL compared to those with HL and MM (p-value = 0.017). Gram-negative and fungal infections were strong predictors of mortality.

conclusionBacterial gram-positive and gram-negative infections were the most common early infections among patients who underwent autologous HSCT for hematological malignancies (HM) in the only center in Palestine. The findings of this study are informative to healthcare providers and planners of care for patients who are scheduled to receive autologous HSCT for HM.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationLymphoma, Non-HodgkinMultiple MyelomaAdultHumansNeoplasm Recurrence, LocalRetrospective StudiesAutologous hematopoietic stem cell transplantationHodgkin’s lymphomaInfectionMortalityMultiple myelomaNon-Hodgkin’s lymphoma

Identifiers

PMID36071381
PMCPMC9449926
OpenAlexW4294876447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.