Evidence map›Paper›PMID 36071192›Full record

ReviewNature2022

Capillary forces generated by biomolecular condensates.

Bernardo Gouveia, Yoonji Kim, Joshua W Shaevitz, Sabine Petry, Howard A Stone, Clifford P Brangwynne

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Review
  8. Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Capillary bundling of microtubules by condensates.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Condensate-mediated shape transformations of cellular membranes by capillary forces.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bernardo Gouveia *Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Yoonji Kim *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-1780-370X
Joshua W ShaevitzDepartment of Physics, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-8809-4723
Sabine PetryDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8537-9763
Howard A StoneDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, USA. hastone@princeton.edu.ORCID http://orcid.org/0000-0002-9670-0639
Clifford P BrangwynneDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu.ORCID http://orcid.org/0000-0002-1350-9960

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Liquid-liquid phase separation and related phase transitions have emerged as generic mechanisms in living cells for the formation of membraneless compartments or biomolecular condensates. The surface between two immiscible phases has an interfacial tension, generating capillary forces that can perform work on the surrounding environment. Here we present the physical principles of capillarity, including examples of how capillary forces structure multiphase condensates and remodel biological substrates. As with other mechanisms of intracellular force generation, for example, molecular motors, capillary forces can influence biological processes. Identifying the biomolecular determinants of condensate capillarity represents an exciting frontier, bridging soft matter physics and cell biology.

Indexed as

Biomolecular CondensatesCell BiologyPhase Transition

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.