ArticleNature2022
A RORγt
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 174 papers.
0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
174 citing papers in PubMed, 238 citations in OpenAlex.
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- Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.Nature immunology · 2026Article
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- Runx-CBFβ regulates the development of tolerogenic Thetis cells.Nature immunology · 2026Article
- Precision Immunoregulation in transplantation: The rise of engineered Treg therapies.Molecular biology reports · 2026Review
- [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine.The Journal of experimental medicine · 2026Article
- Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution.Nature reviews. Rheumatology · 2026Review
- Artificial Intelligence-Driven Construction of Predictive and Druggable Frameworks to an In Silico Bioengineering Evidence Support for Therapy of Esophageal Squamous Cell Carcinoma Patients: Insights from a Toll-like Receptor Signal with Th17 and T Helper Microenvironment.Bioengineering (Basel, Switzerland) · 2026Article
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- Article
- Article
- Review
- ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation.Mucosal immunology · 2026Article
- Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88.Scandinavian journal of immunology · 2026Article
- Identification and characterization of dietary antigens in oral tolerance.Science immunology · 2026Article
- The development of innate lymphoid cells.Nature immunology · 2026Review
114 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
23 authors at 11 institutions in 4 countries.
Ranit KedmiMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Tariq A NajarMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Kailin R MesaMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4452-9048
Allyssa GraysonMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Lina KroehlingMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Yuhan HaoCenter for Genomics and Systems Biology, New York University, New York, NY, USA.
Stephanie HaoTechnology Innovation Lab, New York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1700-9699
Maria PokrovskiiMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Mo XuMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Jhimmy TalbotMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Jiaxi WangDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Joe GerminoDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3939-3342
Caleb A LareauDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4179-4807
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5167-537X
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3093-4758
Terri M LauferDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Iannis AifantisDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Juliet M BartlesonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Paul M AllenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-3796-6047
Helena PaidassiCIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, ENS de Lyon, Lyon, France.
James M GardnerDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3470-9520
Marlon StoeckiusTechnology Innovation Lab, New York Genome Center, New York, NY, USA.
Dan R LittmanMolecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA. dan.littman@med.nyu.edu.ORCID http://orcid.org/0000-0002-2850-8688
New York University · USUniversity of California, San Francisco · USGladstone Institutes · USHoward Hughes Medical Institute · USNew York Genome Center · USWashington University in St. Louis · US10X Genomics (Sweden) · SEFred Hutch Cancer Center · USNational Institute of Biological Sciences, Beijing · CNPhiladelphia VA Medical Center · USUniversité Claude Bernard Lyon 1 · FR
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1MSingle-cell Mapping Center for Human Regulatory Elements and Gene ActivityUM1HG012076 · NHGRI · STANFORD UNIVERSITY · PI Michael Ryan Corces, Ansuman Satpathy · 2021 to 2026
$13.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MDeterminants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaR01AI158687 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dan Littman · 2021 to 2026
$3.2MStrength of TCR:self-pMHC interactions in the periphery instructs CD4+ T help cell responsesR01AI139540 · NIAID · WASHINGTON UNIVERSITY · PI MORLEY, SHARON CELESTE · 2019 to 2023
$2.3MScanning Electron Microscope with 3ViewS10OD019974 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, FENGXIA · 2016 to 2016
$1.1MInverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500kVentana Medical Systems Discovery XTS10OD010584 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHIRIBOGA, LUIS A · 2013 to 2013
$127kSandy Recovery Ventana Medical Systems Discovery XTS10OD018338 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHIRIBOGA, LUIS A · 2014 to 2014
$123kDefining the Role of Aire in eTACs and its Contribution to Peripheral Immune ToleranceF31AI172348 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, JIAXI · 2022 to 2024
$120kHoward Hughes Medical InstituteNCI NIH HHS P30 CA016087NCRR NIH HHS S10 RR023704NHGRI NIH HHS UM1 HG012076NIAID NIH HHS F31 AI172348NIAID NIH HHS R01 AI139540NIAID NIH HHS R01 AI158687NIAID NIH HHS T32 AI007334NIH HHS S10 OD010584NIH HHS S10 OD018338NIH HHS S10 OD019974
Abstract
The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment
Indexed as
Cell DifferentiationGastrointestinal MicrobiomeNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryAntigen PresentationAntigen-Presenting CellsDendritic CellsHomeostasisImmunity, InnateIntegrin alphaVReceptors, CCR7Th17 CellsTransforming Growth Factor betaIntegrin alphaVNuclear Receptor Subfamily 1, Group F, Member 3Receptors, CCR7Transforming Growth Factor beta
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.