Evidence map›Paper›PMID 36071159›Full record

ArticleNature2022

A phosphoinositide signalling pathway mediates rapid lysosomal repair.

Jay Xiaojun Tan, Toren Finkel

Open access · bronzeAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 1 pooled it
36.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 1 synthesis or guideline pooled it, 339 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Article
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  7. Article
  8. Review
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  15. LRRK2: Molecular Mechanisms in Parkinson's Disease.International journal of molecular sciences · 2026
    Review
  16. Article
  17. Article
  18. Review
  19. Selective autophagy in kidney health and disease.Nature reviews. Nephrology · 2026
    Review
  20. Article

173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jay Xiaojun TanAging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. jay.tan@pitt.edu.ORCID http://orcid.org/0000-0003-3300-2240
Toren FinkelAging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. finkelt@pitt.edu.ORCID http://orcid.org/0000-0002-0726-3546
University of Pittsburgh · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
The role of calcium entry through the mitochondrial uniporter in regulating cardiac metabolism and physiologyR01HL142589 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN · 2019 to 2022
$2.6M
Vascular autophagy as a mediator of vascular aging and homeostasisR01HL142663 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN · 2018 to 2021
$2.2M
Antagonizing tau spreading in Alzheimer’s disease by PI4K2A-mediated lysosomal quality controlK01AG075142 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAN, XIAOJUN · 2022 to 2023
$247k
NHLBI NIH HHS R01 HL142589NHLBI NIH HHS R01 HL142663NIA NIH HHS K01 AG075142NIA NIH HHS P30 AG024827NIA NIH HHS U54 AG075931
6 · The paper itself

Abstract

Lysosomal dysfunction has been increasingly linked to disease and normal ageing

Indexed as

LysosomesPhosphatidylinositolsSignal TransductionAutophagy-Related ProteinsBiological TransportCholesterolEndoplasmic ReticulumIntracellular SpaceOxysterol Binding ProteinsOxysterolsPhosphatidylinositol PhosphatesPhosphatidylserinesPhosphotransferases (Alcohol Group Acceptor)ProteomicsReceptors, SteroidAutophagy-Related ProteinsCholesterolOxysterol Binding ProteinsOxysterolsphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphatidylserinesPhosphotransferases (Alcohol Group Acceptor)Receptors, Steroid

Identifiers

PMID36071159
PMCPMC9450835
OpenAlexW4294904414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.