Evidence map›Paper›PMID 36071158›Full record

ArticleNature2022

Brainstem ADCYAP1

Anoj Ilanges, Rani Shiao, Jordan Shaked, Ji-Dung Luo, Xiaofei Yu, Jeffrey M Friedman

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
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  8. Article
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  14. PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026
    Article
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anoj IlangesLaboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Rani ShiaoLaboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Jordan ShakedLaboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Ji-Dung LuoBioinformatics Resource Center, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0150-1440
Xiaofei YuState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-1712-331X
Jeffrey M FriedmanHoward Hughes Medical Institute, The Rockefeller University, New York, NY, USA. friedj@rockefeller.edu.ORCID http://orcid.org/0000-0003-2152-0868
Rockefeller University · USFudan University · CNHoward Hughes Medical Institute · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Infections induce a set of pleiotropic responses in animals, including anorexia, adipsia, lethargy and changes in temperature, collectively termed sickness behaviours

Indexed as

Brain StemIllness BehaviorNeuronsAnimalsAnorexiaArea PostremaLethargyLipopolysaccharidesMicePituitary Adenylate Cyclase-Activating PolypeptideProto-Oncogene Proteins c-fosSolitary NucleusAdcyap1 protein, mouseFos protein, mouseLipopolysaccharidesPituitary Adenylate Cyclase-Activating PolypeptideProto-Oncogene Proteins c-fos

Identifiers

PMID36071158
PMCPMC9492535
OpenAlexW4294904953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.