ArticleNature2022
Identification of trypsin-degrading commensals in the large intestine.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Diabetes-associatedMicrobiology spectrum · 2026Observational
- Immune Cell-Mediated Causal Link Between Gut Microbiota Traits and Childhood Asthma: Evidence From Mendelian Randomization and Metagenomic Sequencing.The clinical respiratory journal · 2026Article
- A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier.Signal transduction and targeted therapy · 2026Article
- Article
- Transcriptome, Proteome, and Metabolome Features in Diarrhea Challenge of Preweaning Piglets via Multi-Omics Integration Analyses.Animals : an open access journal from MDPI · 2026Article
- Engineering Microbial Particles for Next-Generation Biomedical Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Integrated omics reveal the effects of vitamin D deficiency on gut microbiota and plasma metabolism in experimental autoimmune uveitis.Journal of neuroinflammation · 2026Article
- Isolation and Mechanistic Characterization ofFoods (Basel, Switzerland) · 2026Article
- Investigation of Storage Conditions and Quality Control Markers for Metabolites and Lipids in Human Feces.Metabolites · 2026Article
- Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression.Alimentary pharmacology & therapeutics · 2026Article
- Microbially derived essential amino acids compensate for dietary deficiencies in an ecologically relevant mammalian host.The ISME journal · 2026Article
- Viable gut bacterial metrics associated with intestinal eubiosis and dysbiosis.Gut microbes reports · 2026Article
- Sex-specific associations between gut microbiota and myopia in adolescents: a clinical predictive modeling study.Frontiers in cellular and infection microbiology · 2026Article
- MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesisFrontiers in microbiology · 2026Article
- Proteases in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- High-zinc diets accelerate molting and recovery by remodeling the cecal microbiome in laying hens.Frontiers in microbiology · 2026Article
- Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats.Nature communications · 2025Article
- Grassland Saline-Alkaline Degradation-Induced Excessive Iron and Sodium Intake Potentially Increases the Transmission Risk of Fecal Pathogenic Bacteria in Cattle.Animals : an open access journal from MDPI · 2025Article
- Gut microbiota-mediated modulation of host amino acid availability and metabolism.Gut microbes · 2025Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 11 institutions in 3 countries.
Youxian Li *RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Eiichiro Watanabe *RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-2050-3740
Yusuke Kawashima *RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-9779-8199
Damian R PlichtaInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6555-2557
Zhujun WangRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Makoto UjikeFaculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7145-7126
Qi Yan AngInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9788-1283
Runrun WuInterdisciplinary Life Science-PULSe, Purdue University, West Lafayette, IN, USA.
Munehiro FuruichiDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7742-1135
Kozue TakeshitaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Koji YoshidaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0466-8994
Keita NishiyamaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Sean M KearneyDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Wataru SudaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Masahira HattoriRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Satoshi SasajimaDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Takahiro MatsunagaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Xiaoxi ZhangRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kazuto WatanabeJSR-Keio University Medical and Chemical Innovation Center, Keio University School of Medicine, Tokyo, Japan.
Jun FujishiroDepartment of Pediatric Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Jason M NormanVedanta Biosciences, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5049-8415
Bernat OlleVedanta Biosciences, Cambridge, MA, USA.
Shutoku MatsuyamaDepartment of Virology III, National Institute of Infectious Diseases, Tokyo, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Yoshifumi UwaminoDepartment of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0717-7450
Osamu OharaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-3328-9571
Ramnik J XavierInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5167
Koji AtarashiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kojiatarashi@keio.jp.ORCID http://orcid.org/0000-0001-5422-0736
Kenya HondaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kenya@keio.jp.ORCID http://orcid.org/0000-0001-8937-9835
Keio University · JPBroad Institute · USKazusa DNA Research Institute · JPRIKEN Center for Integrative Medical Sciences · JPVedantra Pharmaceuticals (United States) · USNational Institute of Infectious Diseases · JPNippon Veterinary and Life Science University · JPPurdue University West Lafayette · USThe University of Tokyo · JPUniversity of Oslo · NOWaseda University · JP
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MIdentification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, XAVIER, RAMNIK J · 2017 to 2021
$3.3MNCCIH NIH HHS R01 AT009708NIDDK NIH HHS P30 DK043351
Abstract
Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions
Indexed as
Gastrointestinal MicrobiomeIntestine, LargeSymbiosisTrypsinAdministration, OralAnimalsBacterial Secretion SystemsBacterial VaccinesBacteroidetesCitrobacter rodentiumCOVID-19DiarrheaFecesHumansImmunoglobulin AMiceBacterial Secretion SystemsBacterial VaccinesImmunoglobulin ATrypsin
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.