Evidence map›Paper›PMID 36071113›Full record

ArticleMolecular psychiatry2022

Decreased basal ganglia and thalamic iron in early psychotic spectrum disorders are associated with increased psychotic and schizotypal symptoms.

Yu Veronica Sui, Faye McKenna, Hilary Bertisch, Pippa Storey, Rebecca Anthopolos, Donald C Goff, Alexey Samsonov, Mariana Lazar

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025
    Article
  6. Article
  7. Article
  8. Iron deficiency in Morgellons disease: unveiling the link.Archives of dermatological research · 2025
    Article
  9. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  10. Iron imbalance in neurodegeneration.Molecular psychiatry · 2024
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yu Veronica SuiDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA. veronica.suiyu@nyu.edu.ORCID http://orcid.org/0000-0003-3910-984X
Faye McKennaDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Hilary BertischThe Zucker Hillside Hospital, Northwell Health, Queens, New York, NY, USA.
Pippa StoreyDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1915-7860
Rebecca AnthopolosDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Donald C GoffDepartment of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Alexey SamsonovDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Mariana LazarDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9285-8124
New York University · USNathan Kline Institute for Psychiatric Research · USNorthwell Health · USUniversity of Wisconsin–Madison · US

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum DisordersR01MH108962 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LAZAR, MARIANA · 2016 to 2020
$2.5M
Macromolecular Imaging of Gray and White Matter Pathology in Multiple SclerosisR01EB027087 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI SAMSONOV, ALEXEY · 2018 to 2021
$1.6M
NIA NIH HHS P30 AG066512NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB027087NIMH NIH HHS R01 MH108962
6 · The paper itself

Abstract

Iron deficits have been reported as a risk factor for psychotic spectrum disorders (PSD). However, examinations of brain iron in PSD remain limited. The current study employed quantitative MRI to examine iron content in several iron-rich subcortical structures in 49 young adult individuals with PSD (15 schizophrenia, 17 schizoaffective disorder, and 17 bipolar disorder with psychotic features) compared with 35 age-matched healthy controls (HC). A parametric approach based on a two-pool magnetization transfer model was applied to estimate longitudinal relaxation rate (R

Indexed as

IronPsychotic DisordersBasal GangliaBrainHumansMagnetic Resonance ImagingThalamusYoung AdultIron

Identifiers

PMID36071113
PMCPMC9772130
OpenAlexW4294874923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.