Evidence map›Paper›PMID 36071108›Full record

ArticleMolecular psychiatry2022

Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium.

Laura S van Velzen, Maria R Dauvermann, Lejla Colic, Luca M Villa, Hannah S Savage, Yara J Toenders, Alyssa H Zhu, Joanna K Bright, Adrián I Campos, Lauren E Salminen and 69 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  5. Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

79 authors at 20 institutions in 11 countries.

Laura S van VelzenOrygen, Parkville, VIC, Australia. laura.vanvelzen@unimelb.edu.au.ORCID http://orcid.org/0000-0002-6003-5227
Maria R DauvermannDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2873-8512
Lejla ColicDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Luca M VillaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5091-6410
Hannah S SavageCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Yara J ToendersOrygen, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-4117-1143
Alyssa H ZhuImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Joanna K BrightImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Adrián I CamposDepartment of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-3468-8619
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sonia AmbrogiLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-2897-358X
Rosa Ayesa-ArriolaDepartment of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.ORCID http://orcid.org/0000-0003-0570-5352
Nerisa BanajLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Zeynep BaşgözeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0306-4849
Jochen BauerUniversity Clinic for Radiology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-9345-2126
Karina BlairCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.
Robert James BlairCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.
Katharina BroschDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.ORCID http://orcid.org/0000-0002-0526-8095
Yuqi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical College, Kunming, China.
Romain ColleMOODS Team, CESP, INSERM U1018, Faculté de Médecine, Univ Paris-Saclay, Le Kremlin Bicêtre, 94275, France.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.ORCID http://orcid.org/0000-0002-4051-3682
Emmanuelle CorrubleMOODS Team, CESP, INSERM U1018, Faculté de Médecine, Univ Paris-Saclay, Le Kremlin Bicêtre, 94275, France.
Baptiste Couvy-DuchesneInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.
Benedicto Crespo-FacorroCentro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Sevilla, Spain.
Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9631-3770
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7117-2908
Christopher G DaveyDepartment of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-1431-3852
Katharina DohmInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Janice M FullertonNeuroscience Research Australia, Randwick, NSW, Australia.ORCID http://orcid.org/0000-0003-4014-4490
Ali Saffet GonulSoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey.ORCID http://orcid.org/0000-0003-3522-1359
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, USA.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Ben J HarrisonMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Mengxin HeDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical College, Kunming, China.ORCID http://orcid.org/0000-0003-2714-3565
Ian B HickieBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0001-8832-9895
Tiffany C HoDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4500-6364
Frank IorfinoBrain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
Andreas JansenDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Fabrice JollantDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Bonnie Klimes-DouganUniversity of Minnesota, Department of Psychology, Minneapolis, MN, USA.
Melissa KlugInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Adam Bryant MillerMental Health Risk and Resilience Research Program, RTI International, Research Triangle Park, NC, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Kensington, NSW, Australia.
Benson MwangiCenter Of Excellence On Mood Disorders, The University of Texas-Health Science Center at Houston, Houston, TX, USA.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Amar OjhaCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-1038-0225
Bronwyn J OversNeuroscience Research Australia, Randwick, NSW, Australia.ORCID http://orcid.org/0000-0002-7138-5556
Julia-Katharina PfarrDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0003-3566-5494
Kai G RingwaldDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.ORCID http://orcid.org/0000-0001-5886-6745
Gloria RobertsSchool of Psychiatry, University of New South Wales, Kensington, NSW, Australia.
Georg RomerDepartment of Child & Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
Marsal SanchesCenter Of Excellence On Mood Disorders, The University of Texas-Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6993-6822
Margaret A SheridanDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jair C SoaresCenter Of Excellence On Mood Disorders, The University of Texas-Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5466-5628
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-7432-4249
Frederike SteinDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Giana I TeresiDepartment of Psychology, Stanford University, Stanford, CA, USA.
Diana Tordesillas-GutiérrezDepartment of Radiology, IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.ORCID http://orcid.org/0000-0003-1458-3932
Aslihan Uyar-DemirSoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey.ORCID http://orcid.org/0000-0002-0856-4260
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven J van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Robert R J M VermeirenChild and Adolescent Psychiatry Leiden University Medical Center, Leiden, The Netherlands.
Alexandra WinterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-3759-1425
Mon-Ju WuCenter Of Excellence On Mood Disorders, The University of Texas-Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0540-8027
Tony T YangDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, UCSF, San Francisco, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Miguel E RenteríaDepartment of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4626-7248
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Hilary P BlumbergDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6363-4698
Anne-Laura van HarmelenDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
ENIGMA Suicidal Thoughts and Behaviours Consortium
Lianne SchmaalOrygen, Parkville, VIC, Australia.
University of Münster · DEPhilipps University of Marburg · DELeiden University · NLThe University of Melbourne · AUUniversity of Southern California · USThe University of Texas Health Science Center · USFondazione Santa Lucia · ITInserm · FRUNSW Sydney · AUYale University · USBoys Town · USEge University · TRKunming Medical University · CNThe University of Queensland · AUThe University of Sydney · AUUniversity of Minnesota Medical Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USBaylor College of Medicine · USCentre National de la Recherche Scientifique · FR

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GARWOOD, MICHAEL · 1993 to 2011
$16.3M
Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
Genetics of Hippocampal Deficits in Bipolar DisorderR01MH070902 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2005 to 2015
$5.1M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
A Cross-Sectional and Longitudinal Functional MRI Study of Adolescent DepressionR01MH085734 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, TONY TUNG-I · 2010 to 2014
$2.7M
Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3M
Development of Brain Abnormalities in Bipolar DisorderR01MH069747 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2004 to 2008
$2.0M
A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5M
Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that ConRC1MH088366 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2009 to 2010
$998k
Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)UG3MH111929 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2018 to 2019
$943k
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R61 AT009864NCRR NIH HHS P41 RR008079NIAAA NIH HHS K01 AA027573NIAAA NIH HHS R21 AA027884NIMH NIH HHS K01 MH106805NIMH NIH HHS K01 MH117442NIMH NIH HHS K23 MH090421NIMH NIH HHS R01 MH069747NIMH NIH HHS R01 MH070902NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH129832NIMH NIH HHS R37 MH101495NIMH NIH HHS R61 MH111929NIMH NIH HHS RC1 MH088366NIMH NIH HHS UG3 MH111929
6 · The paper itself

Abstract

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.

Indexed as

Suicidal IdeationSuicide, AttemptedAdolescentBrainHumansMood DisordersNeuroimaging

Identifiers

PMID36071108
PMCPMC9734039
OpenAlexW4294991267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.