ArticleScientific reports2022
Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Diagnostic performance of neuroimaging modalities for epileptogenic focus localization: A systematic review.Epilepsia open · 2026Pooled it
- Beyond FDG: a paradigm shift in precision localization of epileptogenic zones in refractory epilepsy using multimodal molecular imaging (PET/CT) and isotropic 3D MRI fusion.Journal of neurology · 2026Review
- Review
- Multimodal neuroimaging fusion in presurgical evaluation of drug-resistant epilepsy: current evidence, clinical integration, and future directions.Frontiers in neuroscience · 2026Review
- Advanced neuroimaging in pediatric epilepsy surgery: state of the art and future perspectives.Neuroradiology · 2026Review
- Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning.Journal of personalized medicine · 2025Review
- Leveraging interictal multimodal features and graph neural networks for automated planning of epilepsy surgery.Brain communications · 2025Article
- Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy-A Pilot Study.Clinical neuroradiology · 2024Article
- Yield of non-invasive imaging in MRI-negative focal epilepsy.Journal of neurology · 2024Article
- Arterial spin labeling perfusion MRI applications in drug-resistant epilepsy and epileptic emergency.Acta epileptologica · 2023Review
- Neurological update: structural and functional imaging in epilepsy surgery.Journal of neurology · 2023Review
- The diagnostic value of ictal SPECT-A retrospective, semiquantitative monocenter study.Epilepsia open · 2023Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 ± 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 ± 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.
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