Evidence map›Paper›PMID 36071081›Full record

ArticleScientific reports2022

Improving ascertainment of suicidal ideation and suicide attempt with natural language processing.

Cosmin A Bejan, Michael Ripperger, Drew Wilimitis, Ryan Ahmed, JooEun Kang, Katelyn Robinson, Theodore J Morley, Douglas M Ruderfer, Colin G Walsh

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Using transfer learning to improve prediction of suicide risk in acute care hospitals.Journal of the American Medical Informatics Association : JAMIA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cosmin A BejanDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA. adi.bejan@vanderbilt.edu.
Michael RippergerDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA.
Drew WilimitisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA.
Ryan AhmedDepartment of Medicine, Vanderbilt University Medical Center, Nashville, USA.
JooEun KangDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Katelyn RobinsonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA.
Theodore J MorleyDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Douglas M RuderferDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA.
Colin G WalshDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 1500, Nashville, TN, 37232, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
PsycheMERGE: Leveraging electronic health records and genomics for mental health researchR01MH118233 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DAVIS, LEA K, SMOLLER, JORDAN W · 2019 to 2022
$3.1M
Distinguishing Clinical and Genetic Risk of Suicidal Ideation from Attempts to Inform PreventionR01MH121455 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RUDERFER, DOUGLAS, WALSH, COLIN GEORGE · 2020 to 2024
$2.7M
2/2 Leveraging electronic health records for pharmacogenomics of psychiatric diordersR01MH116269 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RUDERFER, DOUGLAS, WALSH, COLIN GEORGE · 2019 to 2022
$1.7M
NIMH NIH HHS R01 MH118233NIMH NIH HHS R01 MH121455
6 · The paper itself

Abstract

Methods relying on diagnostic codes to identify suicidal ideation and suicide attempt in Electronic Health Records (EHRs) at scale are suboptimal because suicide-related outcomes are heavily under-coded. We propose to improve the ascertainment of suicidal outcomes using natural language processing (NLP). We developed information retrieval methodologies to search over 200 million notes from the Vanderbilt EHR. Suicide query terms were extracted using word2vec. A weakly supervised approach was designed to label cases of suicidal outcomes. The NLP validation of the top 200 retrieved patients showed high performance for suicidal ideation (area under the receiver operator curve [AUROC]: 98.6, 95% confidence interval [CI] 97.1-99.5) and suicide attempt (AUROC: 97.3, 95% CI 95.2-98.7). Case extraction produced the best performance when combining NLP and diagnostic codes and when accounting for negated suicide expressions in notes. Overall, we demonstrated that scalable and accurate NLP methods can be developed to identify suicidal behavior in EHRs to enhance prevention efforts, predictive models, and precision medicine.

Indexed as

Suicidal IdeationSuicide, AttemptedElectronic Health RecordsHumansInformation Storage and RetrievalNatural Language Processing

Identifiers

PMID36071081
PMCPMC9452591

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.