Evidence map›Paper›PMID 36071069›Full record

ArticleScientific data2022

TRFs and tiRNAs sequence in acute rejection for vascularized composite allotransplantation.

Yuan Fang, Haibo Li, Jingting Chen, Yao Xiong, Xu Li, Binbin Sun, Shengli Li, Jianda Zhou, Shoubao Wang

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yuan FangDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0001-6124-9377
Haibo LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jingting ChenDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao XiongDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Binbin SunCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
Shengli Li *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drlishengli@sina.com.
Jianda Zhou *Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zhoujianda@csu.edu.cn.
Shoubao Wang *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wxldragon198418@163.com.
Central South University · CNShanghai Jiao Tong University · CNDonghua University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 2018ZX10303502National Natural Science Foundation of China (National Science Foundation of China) 82002065
6 · The paper itself

Abstract

Illumina tRFs & tiRNAs-seq analysis was used to characterize the whole transcriptomes of acute rejection caused by vascularized composite allotransplantation (VCA). tRFs & tiRNAs-seq information for muscle samples with VCA was obtained and compared with similar information for same age- and sex-matched healthy control subjects. The expression of 16 tRFs and tiRNAs, including 5 up-regulated target genes and 11 down-regulated target genes, were significantly different. According to bioinformatics analysis and reverse transcription quantitative polymerase chain reaction, we speculate that tiRNA-1-34-Glu-CTC-1 plays an important role in VCA-induced acute rejection by regulating the CACNA1D gene in the MAPK signaling pathway The findings provide the whole-transcriptome signatures of acute rejection for VCA, allowing further exploration of gene expression patterns/signatures associated with the various clinical symptoms of acute rejection for VCA.

Indexed as

RNA, Small UntranslatedTranscriptomeVascularized Composite AllotransplantationHumansSignal TransductionRNA, Small Untranslated

Identifiers

PMID36071069
PMCPMC9452673
OpenAlexW4294991303

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.