ArticleNature2022
Novel antigen-presenting cell imparts T
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers.
0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed
18.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 240 citations in OpenAlex.
- T cell fate is dictated by different antigen-presenting cells in response to dietary versus gut epithelial self-antigen.Immunity · 2026Article
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
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- Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.Nature immunology · 2026Article
- MaternalBiomedicines · 2026Article
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- Maternal and infant gut microbiome.iMeta · 2026Review
- Runx-CBFβ regulates the development of tolerogenic Thetis cells.Nature immunology · 2026Article
- [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution.Nature reviews. Rheumatology · 2026Review
- B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine.The Journal of experimental medicine · 2026Article
- Early-life Gut Microbiota and Allergic Diseases: Immune Regulatory Mechanisms and Intervention Progress.Clinical reviews in allergy & immunology · 2026Review
- Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells.Nature communications · 2026Article
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- Dendritic cells as orchestrators in the allergen-specific immunotherapy of allergic diseases.Clinical reviews in allergy & immunology · 2026Review
- Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.Nature immunology · 2026Review
- Article
- Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 4 countries.
Blossom Akagbosu *Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Zakieh Tayyebi *Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7821-9905
Gayathri ShibuImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Yoselin A Paucar IzaImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Deeksha DeepImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA.
Yollanda Franco ParisottoImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Logan FisherImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID http://orcid.org/0000-0003-4680-1527
H Amalia PasolliElectron Microscopy Resource Center, The Rockefeller University, New York, NY, USA.
Valentin ThevinTumor Escape Resistance Immunity Department, CRCL, INSERM U1052, CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-0548-1160
Rasa ElmentaiteWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0001-7366-5466
Maximilian KnottInstitute of PathologyFaculty of Medicine, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6995-3702
Saskia HemmersImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA.ORCID http://orcid.org/0000-0002-5575-0509
Lorenz JahnDepartment of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9880-7026
Christin FriedrichWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Jacob VerterHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3710-6549
Zhong-Min WangHoward Hughes Medical Institute and Immunology Program, Sloan Kettering Institute and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5538-1969
Marcel van den BrinkImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA.ORCID http://orcid.org/0000-0003-0696-4401
Georg GasteigerWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6986-127X
Thomas G P GrünewaldHopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0920-7377
Julien C MarieTumor Escape Resistance Immunity Department, CRCL, INSERM U1052, CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.ORCID http://orcid.org/0000-0001-6713-7923
Christina LeslieComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4571-5910
Alexander Y RudenskyImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine Graduate School of Medical Sciences, New York, NY, USA. rudenska@mskcc.org.ORCID http://orcid.org/0000-0003-1280-2898
Chrysothemis C BrownImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA. brownc10@mskcc.org.ORCID http://orcid.org/0000-0002-5834-926X
Memorial Sloan Kettering Cancer Center · USUniversité Claude Bernard Lyon 1 · FRUniversity of Würzburg · DEGerman Cancer Research Center · DELMU Klinikum · DERockefeller University · USWellcome Sanger Institute · GB
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8MSELF PEPTIDES BOUND TO MHC CLASS II IN T CELL SELECTIONR01AI034206 · NIAID · UNIVERSITY OF WASHINGTON · PI Alexander Y Rudensky · 1998 to 2026
$6.4MAcceptance of non-self: Decoding intestinal immune tolerance during early lifeDP2AI171116 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Chrysothemis Brown · 2022 to 2026
$2.7MDendritic cell heterogeneity and its role in pulmonary fungal infectionF30AI154660 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEEP, DEEKSHA · 2021 to 2024
$204kNCI NIH HHS P30 CA008748NCI NIH HHS U54 CA209975NIAID NIH HHS DP2 AI171116NIAID NIH HHS F30 AI154660NIAID NIH HHS R01 AI034206NIGMS NIH HHS T32 GM007739Wellcome Trust 201483/Z/16/ZWellcome Trust WT201483/Z/16/Z
Abstract
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (T
Indexed as
Antigen-Presenting CellsDendritic CellsEpithelial CellsGastrointestinal MicrobiomeImmune ToleranceThymus GlandT-Lymphocytes, RegulatoryCell DifferentiationImmunity, InnateIntegrinsLymph NodesNuclear Receptor Subfamily 1, Group F, Member 3Transforming Growth Factor betaintegrin alphavbeta8IntegrinsNuclear Receptor Subfamily 1, Group F, Member 3Transforming Growth Factor beta
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.