Evidence map›Paper›PMID 36070796›Full record

ArticleNature2022

Gut-brain circuits for fat preference.

Mengtong Li, Hwei-Ee Tan, Zhengyuan Lu, Katherine S Tsang, Ashley J Chung, Charles S Zuker

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  7. Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Fatty acid regulation of feeding inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026
    Article
  19. Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  20. Mechanisms and clinical implications of gut-brain interactions.The Journal of clinical investigation · 2026
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mengtong LiHoward Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Chevy Chase, MD, USA.ORCID http://orcid.org/0000-0001-6967-7237
Hwei-Ee TanHoward Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Chevy Chase, MD, USA.
Zhengyuan LuZuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4262-1193
Katherine S TsangHoward Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Chevy Chase, MD, USA.
Ashley J ChungHoward Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Chevy Chase, MD, USA.
Charles S ZukerHoward Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Chevy Chase, MD, USA. cz2195@columbia.edu.ORCID http://orcid.org/0000-0002-5201-8718
Howard Hughes Medical Institute · USAgency for Science, Technology and Research · SGColumbia University · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

The perception of fat evokes strong appetitive and consummatory responses

Indexed as

BrainBrain-Gut AxisFood PreferencesIntestinesNeuronsAmino AcidsAnimalsMiceSingle-Cell AnalysisSugarsVagus NerveAmino AcidsSugars

Identifiers

PMID36070796
PMCPMC9605869
OpenAlexW4294904545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.