ArticleScience advances2022
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Review
- Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization.Nature communications · 2025Article
- Immunolocalization and proteomic analyses of IZUMO1 in porcine spermatozoa.Frontiers in cell and developmental biology · 2025Article
- Article
- No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1.Science advances · 2024Article
- Molecular dynamics of JUNO-IZUMO1 complexation suggests biologically relevant mechanisms in fertilization.Scientific reports · 2023Article
- A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization.Biomolecules · 2023Review
- A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion.The Journal of cell biology · 2023Article
- Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep.Frontiers in cell and developmental biology · 2023Article
- Juno and CD9 protein network organization in oolemma of mouse oocyte.Frontiers in cell and developmental biology · 2023Article
- Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 12 institutions in 5 countries.
Jana VondrakovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0003-3994-348X
Michaela FrolikovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-9834-8405
Lukas DedLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0003-1053-4025
Jiri CernyLaboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-1969-9304
Pavla PostlerovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-5090-4652
Veronika PalenikovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Ondrej SimonikLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-6577-765X
Zuzana NahackaLaboratory of Molecular Therapy, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Krystof BasusLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-0617-5042
Eliska ValaskovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-0737-7770
Radek MachanImaging Methods Core Facility at BIOCEV, Faculty of Science, Charles University, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-4064-7277
Allan PaceyDepartment of Oncology and Metabolism, University of Sheffield, Medical School, Sheffield S10 2RX, UK.ORCID 0000-0002-4387-8871
Zuzana HolubcovaReprofit International, Clinic of Reproductive Medicine, Brno, Czech Republic.ORCID 0000-0002-4658-6161
Pavel KoubekProCrea Swiss IVF Center, Prague, Czech Republic.
Zuzana EzrovaLaboratory of Molecular Therapy, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-4174-6066
Soojin ParkResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID 0000-0002-9901-719X
Ruiwu LiuDepartment of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA.
Raghavendran ParthaDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7900-4375
Nathan ClarkDepartment of Human Genetics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-0006-8374
Jiri NeuzilLaboratory of Molecular Therapy, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID 0000-0001-9859-6217
Kent EricksonDepartment of Cell Biology and Human Anatomy, University of California, Davis, School of Medicine, Davis, CA, USA.ORCID 0000-0001-6534-4312
Kit S LamDepartment of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA.ORCID 0000-0002-3076-6969
Harry MooreCentre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0003-1789-6600
Katerina KomrskovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.ORCID 0000-0002-6837-2148
Czech Academy of Sciences, Institute of Biotechnology · CZUniversity of California, Davis · USCharles University · CZCzech Academy of Sciences · CZThe University of Osaka · JPUniversity of Sheffield · GBCzech University of Life Sciences Prague · CZGriffith University · AUMasaryk University · CZMinistry of Finance of the Czech Republic · CZUniversity of Pittsburgh · USUniversity of Utah · US
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9MTitle: Functional Annotation of Genomes via Phenotypic Convergence within Large Multi-species AlignmentsR01HG009299 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria D Chikina, Nathaniel L Clark · 2017 to 2026
$4.1MDiscovery and characterization of ocular regulatory elements through evolutionary analysisR01EY030546 · NEI · UNIVERSITY OF UTAH · PI CHIKINA, MARIA D, CLARK, NATHANIEL L · 2020 to 2024
$2.4MNCI NIH HHS P30 CA093373NEI NIH HHS R01 EY030546NHGRI NIH HHS R01 HG009299
Abstract
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.