ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Clinical Spectrum of Anti-SEZ6L2 Syndrome: A Case Report With Brain Volumetry and Systematic Literature Review.Neurology(R) neuroimmunology & neuroinflammation · 2026Pooled it
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Autopsy-Confirmed Non-Paraneoplastic Lambert-Eaton Myasthenic Syndrome with Cerebellar Degeneration: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Immunopathological mechanisms in autoimmune encephalitis: from pathogenesis to targeted therapies.Frontiers in immunology · 2026Review
- Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens.Acta neuropathologica · 2025Article
- Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets.Neuron · 2025Review
- Roles of CDR2 and CDR2L in Anti-Yo Paraneoplastic Cerebellar Degeneration: A Literature Review.International journal of molecular sciences · 2024Review
- Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies: Case Report and Potential Mechanisms.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Clinical Course of Neurologic Adverse Events Associated With Immune Checkpoint Inhibitors: Focus on Chronic Toxicities.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Opsoclonus-Ataxia Syndrome in a Patient With Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Diagnostic and prognostic biomarkers in immune checkpoint inhibitor-related encephalitis: a retrospective cohort study.The Lancet regional health. Europe · 2024Article
- Recent Advances in Immune-Mediated Cerebellar Ataxias: Pathogenesis, Diagnostic Approaches, Therapies, and Future Challenges-Editorial.Brain sciences · 2023Article
- Paraneoplastic Neurological Syndromes of the Central Nervous System: Pathophysiology, Diagnosis, and Treatment.Biomedicines · 2023Review
- An examination of plasma autoantibodies against voltage gated calcium channels in schizophrenia.Brain, behavior, & immunity - health · 2023Article
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Authors and funding
14 authors at 1 institution in 2 countries.
Michael WinklehnerFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.ORCID 0000-0003-4938-7827
Jan BauerFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Verena EndmayrFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Carmen SchwaigerFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Gerda RickenFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.ORCID 0000-0003-0388-7965
Masakatsu MotomuraFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Shunsuke YoshimuraFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Hiroshi ShintakuFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Kinya IshikawaFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Yukio TsuuraFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Takahiro IizukaFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Takanori YokotaFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Takashi IriokaFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan.
Romana HöftbergerFrom the Division of Neuropathology and Neurochemistry (M.W., V.E., C.S., G.R., R.H.), Department of Neurology, and Department of Neuroimmunology (J.B.), Center for Brain Research, Medical University of Vienna, Austria; Department of Electrical and Electronics Engineering (M.M.), Faculty of Engineering, Nagasaki Institute of Applied Science; Department of Neurology and Strokology (S.Y.), Nagasaki University Hospital; Neurology Clinic with Neuromorphomics Laboratory (H.S.), Nitobe Memorial Nakano General Hospital, Tokyo; Division of Surgical Pathology (H.S.), Tokyo Medical and Dental University Hospital; The Center for Personalized Medicine for Healthy Aging (K.I.), Tokyo Medical and Dental University; Departments of Diagnostic Pathology and Clinical Laboratory (Y.T.), Yokosuka Kyosai Hospital, Kanagawa; Department of Neurology (T. Iizuka), Kitasato University School of Medicine, Kanagawa; Department of Neurology and Neurological Science (T.Y.), Graduate School, Tokyo Medical and Dental University; and Department of Neurology (T. Irioka), Yokosuka Kyosai Hospital, Kanagawa, Japan. romana.hoeftberger@meduniwien.ac.at.
Tokyo Medical and Dental University · JP
Funding
Austrian Science Fund FWF DOC 33Austrian Science Fund FWF I 4685
Abstract
BACKGROUND AND
objectivesParaneoplastic cerebellar degeneration (PCD) is characterized by a widespread loss of Purkinje cells (PCs) and may be associated with autoantibodies against intracellular antigens such as Yo or cell surface neuronal antigens such as the P/Q-type voltage-gated calcium channel (P/Q-VGCC). Although the intracellular location of the target antigen in anti-Yo-PCD supports a T cell-mediated pathology, the immune mechanisms in anti-P/Q-VGCC-PCD remain unclear. In this study, we compare neuropathologic characteristics of PCD with anti-P/Q-VGCC and anti-Yo autoantibodies in an archival autopsy cohort.
methodsWe performed neuropathology, immunohistochemistry, and multiplex immunofluorescence on formalin-fixed and paraffin-embedded brain tissue of 1 anti-P/Q-VGCC, 2 anti-Yo-PCD autopsy cases and controls.
resultsAnti-Yo-PCD revealed a diffuse and widespread PC loss together with microglial nodules with pSTAT1 DISCUSSION: Anti-Yo-PCD showed characteristic features of a T cell-mediated pathology, whereas this was not observed in 1 case of anti-P/Q-VGCC-PCD. Our findings support a pathogenic role of anti-P/Q-VGCC autoantibodies in causing neuronal dysfunction, probably due to altered synaptic transmission resulting in calcium dysregulation and subsequent PC death. Because disease progression may lead to irreversible PC loss, anti-P/Q-VGCC-PCD patients could benefit from early oncologic and immunologic therapies.
Indexed as
Paraneoplastic Cerebellar DegenerationAntibodies, NeoplasmAutoantibodiesCalcium Channels, Q-TypeCD8-Positive T-LymphocytesHumansImmunoglobulin GNerve Tissue ProteinsAntibodies, Neoplasmanti-Yo autoantibodiesAutoantibodiesCalcium Channels, Q-TypeImmunoglobulin GNerve Tissue Proteins
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