Evidence map›Paper›PMID 36070048›Full record

ArticleAnnals of biomedical engineering2023

Full and Partial Mid-substance ACL Rupture Using Mechanical Tibial Displacement in Male and Female Mice.

Ariel E Timkovich, Katie J Sikes, Kendra M Andrie, Maryam F Afzali, Joseph Sanford, Kimberli Fernandez, David Joseph Burnett, Emma Hurley, Tyler Daniel, Natalie J Serkova and 2 more

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Muscle-specific ERRγ activation mitigates muscle atrophy after ACL injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ariel E Timkovich *Department of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA.ORCID http://orcid.org/0000-0001-8652-5016
Katie J Sikes *Department of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.ORCID http://orcid.org/0000-0002-3750-4777
Kendra M AndrieDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA.
Maryam F AfzaliDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA.
Joseph SanfordDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA.
Kimberli FernandezDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
David Joseph BurnettDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Emma HurleyDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Tyler DanielDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA.
Natalie J SerkovaDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Tammy Haut DonahueUniversity of Memphis, Memphis, TN, 38152, USA.
Kelly S SantangeloDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 1682 Campus Delivery, Fort Collins, CO, 80523-1621, USA. Kelly.Santangelo@colostate.edu.ORCID http://orcid.org/0000-0002-2348-594X
Colorado State University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Memphis · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Biomedical Research Training for VeterinariansT32OD010437 · OD · COLORADO STATE UNIVERSITY · PI Gregg A Dean, KELLY S SANTANGELO · 2012 to 2026
$6.2M
NCI NIH HHS NCI P30CA046934NIH HHS OD010437NIH HHS UL1TR001082
6 · The paper itself

Abstract

The anterior cruciate ligament (ACL) is the most commonly injured knee ligament. Surgical reconstruction is the gold standard treatment for ACL ruptures, but 20-50% of patients develop post-traumatic osteoarthritis (PTOA). ACL rupture is thus a well-recognized etiology of PTOA; however, little is known about the initial relationship between ligamentous injury and subsequent PTOA. The goals of this project were to: (1) develop both partial and full models of mid-substance ACL rupture in male and female mice using non-invasive mechanical methods by means of tibial displacement; and (2) to characterize early PTOA changes in the full ACL rupture model. A custom material testing system was utilized to induce either partial or full ACL rupture by means of tibial displacement at 1.6 or 2.0 mm, respectively. Mice were euthanized either (i) immediately post-injury to determine rupture success rates or (ii) 14 days post-injury to evaluate early PTOA progression following full ACL rupture. Our models demonstrated high efficacy in inciting either full or partial ACL rupture in male and female mice within the mid-substance of the ACL. These tools can be utilized for preclinical testing of potential therapeutics and to further our understanding of PTOA following ACL rupture.

Indexed as

Anterior Cruciate Ligament InjuriesOsteoarthritisAnimalsAnterior Cruciate LigamentFemaleKnee JointMaleMiceRuptureTibiaAnimal modelsAnterior cruciate ligamentMechanical rupturePost-traumatic osteoarthritisPreclinical model

Identifiers

PMID36070048
OpenAlexW4294916212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.