ArticleEuropean journal of microbiology & immunology2022
Campylobacter jejuni infection induces acute enterocolitis in IL-10-/- mice pretreated with ampicillin plus sulbactam.
Article in European journal of microbiology & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 19 citations in OpenAlex.
- Bee venom-derived exosomes combined with metronidazole: antimicrobial effect on Campylobacter jejuni and fibroblast wound healing model.Molecular biology reports · 2026Article
- Differential antibiosis predisposes mice to Campylobacter jejuni infection: Deeper insights into the impact of the gut microbiota composition in colonization resistance.European journal of microbiology & immunology · 2025Article
- Therapeutic and protective approaches to combatFrontiers in pharmacology · 2025Review
- Therapeutic effects of oral benzoic acid application during acute murine campylobacteriosis.European journal of microbiology & immunology · 2024Article
- Carvacrol prophylaxis improves clinical outcome and dampens apoptotic and pro-inflammatory immune responses upon Campylobacter jejuni infection of human microbiota-associated IL-10-/- mice.European journal of microbiology & immunology · 2024Article
- Menthol Pretreatment AlleviatesBiomolecules · 2024Article
- Oral curcumin ameliorates acute murine campylobacteriosis.Frontiers in immunology · 2024Article
- Oral treatment of human gut microbiota associated IL-10Frontiers in microbiology · 2024Article
- Campylobacter in Africa - A specific viewpoint.European journal of microbiology & immunology · 2023Review
- Prophylactic oral application of resveratrol to alleviate acute campylobacteriosis in human gut microbiota associated IL-10-/- mice.European journal of microbiology & immunology · 2023Article
- Oral application of carvacrol, butyrate, ellagic acid, and 2'-fucosyl-lactose to mice suffering from acute campylobacteriosis - Results from a preclinical placebo-controlled intervention study.European journal of microbiology & immunology · 2023Article
- Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Pharmaceutics · 2023Article
- Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota.Biomolecules · 2023Article
- Human microbiota associated IL-10-/- mice: A valuable enterocolitis model to dissect the interactions of Campylobacter jejuni with host immunity and gut microbiota.European journal of microbiology & immunology · 2023Article
- Metabolomic signatures of intestinal colonization resistance againstFrontiers in microbiology · 2023Article
- Disease alleviating effects following prophylactic lemon and coriander essential oil treatment in mice with acute campylobacteriosis.Frontiers in microbiology · 2023Article
- Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical MurineBiomolecules · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbiota depletion is a pivotal prerequisite to warrant Campylobacter jejuni infection and induced inflammation in IL-10-/- mice used as acute campylobacteriosis model. We here assessed the impact of an 8-week antibiotic regimen of ampicillin, ciprofloxacin, imipenem, metronidazole, and vancomycin (ABx) as compared to ampicillin plus sulbactam (A/S) on gut microbiota depletion and immunopathological responses upon oral C. jejuni infection. Our obtained results revealed that both antibiotic regimens were comparably effective in depleting the murine gut microbiota facilitating similar pathogenic colonization alongside the gastrointestinal tract following oral infection. Irrespective of the preceding microbiota depletion regimen, mice were similarly compromised by acute C. jejuni induced enterocolitis as indicated by comparable clinical scores and macroscopic as well as microscopic sequelae such as colonic histopathology and apoptosis on day 6 post-infection. Furthermore, innate and adaptive immune cell responses in the large intestines were similar in both infected cohorts, which also held true for intestinal, extra-intestinal and even systemic secretion of pro-inflammatory cytokines such as TNF-α, IFN-γ, and IL-6. In conclusion, gut microbiota depletion in IL-10-/- mice by ampicillin plus sulbactam is sufficient to investigate both, C. jejuni infection and the immunopathological features of acute campylobacteriosis.
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