Evidence map›Paper›PMID 36069736›Full record

ArticlemBio2022

Surface Anchoring of the Kingella kingae Galactan Is Dependent on the Lipopolysaccharide O-Antigen.

Nina R Montoya, Eric A Porsch, Vanessa L Muñoz, Artur Muszyński, Jiri Vlach, David K Hahn, Parastoo Azadi, Matthew Sherman, Hyojik Yang, Courtney E Chandler and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Pathogenic determinants ofFrontiers in pediatrics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Nina R MontoyaUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Eric A PorschDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Vanessa L MuñozDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Artur MuszyńskiComplex Carbohydrate Research Center, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Jiri VlachComplex Carbohydrate Research Center, University of Georgiagrid.213876.9, Athens, Georgia, USA.
David K HahnComplex Carbohydrate Research Center, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Matthew ShermanUniversity of Maryland-Baltimore School of Dentistry, Microbial Pathogenesis, Baltimore, Maryland, USA.
Hyojik YangUniversity of Maryland-Baltimore School of Dentistry, Microbial Pathogenesis, Baltimore, Maryland, USA.
Courtney E ChandlerUniversity of Maryland-Baltimore School of Dentistry, Microbial Pathogenesis, Baltimore, Maryland, USA.
Robert K ErnstUniversity of Maryland-Baltimore School of Dentistry, Microbial Pathogenesis, Baltimore, Maryland, USA.ORCID 0000-0001-5016-8694
Joseph W St GemeUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
University of Georgia · USUniversity of Maryland, Baltimore · USChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
MS Diagnostic Bacterial Identification LibraryR01AI147314 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2020 to 2024
$2.3M
Virulence mechanisms in the emerging pathogen Kingella kingaeR01AI121015 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI ST. GEME, JOSEPH W. · 2016 to 2020
$2.1M
NIAID NIH HHS R01 AI121015NIAID NIH HHS R01 AI147314NIGMS NIH HHS R24 GM137782NIGMS NIH HHS T32 GM007229
6 · The paper itself

Abstract

Kingella kingae is a leading cause of bone and joint infections and other invasive diseases in young children. A key K. kingae virulence determinant is a secreted exopolysaccharide that mediates resistance to serum complement and neutrophils and is required for full pathogenicity. The K. kingae exopolysaccharide is a galactofuranose homopolymer called galactan and is encoded by the

Indexed as

Kingella kingaeNeisseriaceae InfectionsChildChild, PreschoolGalactansGlycosyltransferasesHumansLipopolysaccharidesO AntigensPhenethylamines1-phenyl-1-aminomethyletheneGalactansGlycosyltransferasesLipopolysaccharidesO AntigensPhenethylaminesexopolysaccharideGram-negative bacterialipopolysaccharidepathogenesis

Identifiers

PMID36069736
PMCPMC9615999
OpenAlexW4294919631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.