ArticleeLife2022
LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- The evolutionary dynamics between viral mimics and host proteins.Molecular systems biology · 2026Article
- Monkeypox Virus (MPXV) Infection: A Review.Infectious disorders drug targets · 2024Review
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.FEMS microbiology reviews · 2023Article
- Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity.Cell reports · 2023Article
- Vertebrate-tropism of a cressdnavirus lineage implicated by poxvirus gene capture.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses.bioRxiv : the preprint server for biology · 2023Article
- Molecular Mechanisms of Poxvirus Evolution.mBio · 2023Review
- A life LINE for large viruses.eLife · 2022Article
- Article
- Poxvirus Recombination.Pathogens (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
There is ample phylogenetic evidence that many critical virus functions, like immune evasion, evolved by the acquisition of genes from their hosts through horizontal gene transfer (HGT). However, the lack of an experimental system has prevented a mechanistic understanding of this process. We developed a model to elucidate the mechanisms of HGT into vaccinia virus, the prototypic poxvirus. All identified gene capture events showed signatures of long interspersed nuclear element-1 (LINE-1)-mediated retrotransposition, including spliced-out introns, polyadenylated tails, and target site duplications. In one case, the acquired gene integrated together with a polyadenylated host U2 small nuclear RNA. Integrations occurred across the genome, in some cases knocking out essential viral genes. These essential gene knockouts were rescued through a process of complementation by the parent virus followed by nonhomologous recombination during serial passaging to generate a single, replication-competent virus. This work links multiple evolutionary mechanisms into one adaptive cascade and identifies host retrotransposons as major drivers for virus evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.